| Identification | Back Directory | [Name]
rac-((2R,3S)-3-((tert-butoxycarbonyl)amino)-2-hydroxy-4-phenylbutanoyl)-D-leucine | [CAS]
87304-15-2 | [Synonyms]
rac-((2R,3S)-3-((tert-butoxycarbonyl)amino)-2-hydroxy-4-phenylbutanoyl)-D-leucine
L-Leucine, N-[(2S,3R)-3-[[(1,1-dimethylethoxy)carbonyl]amino]-2-hydroxy-1-oxo-4-phenylbutyl]- | [Molecular Formula]
C21H32N2O6 | [MDL Number]
MFCD31631159 | [MOL File]
87304-15-2.mol | [Molecular Weight]
408.49 |
| Hazard Information | Back Directory | [Description]
E3 Ligase ligand 9 targets ubiquitin-protein ligases in order to activate the E3 ubiquitin ligase. It can then treat metabolic disorders and psychiatric disorders. | [Uses]
E3 ligase Ligand 9 is a ligand for E3 ubiquitin ligase. E3 ligase Ligand 9 can be connected to the ligand for protein by a linker to form PROTACs or SNIPERs. PROTACs are inducers of ubiquitination-mediated degradation of cancer-promoting proteins[1]. | [References]
[1] Shibata N, et al. Development of Protein Degradation Inducers of Androgen Receptor by Conjugation of Androgen Receptor Ligands and Inhibitor of Apoptosis Protein Ligands. J Med Chem. 2018 Jan 25;61(2):543-575. DOI:10.1021/acs.jmedchem.7b00168 |
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