| Identification | Back Directory | [Name]
(3S)-1-[(3-chloro-2-methylbenzene)sulfonyl]-
N-cyclohexylpiperidine-3-carboxamide | [CAS]
872506-67-7 | [Synonyms]
(3S)-1-[(3-chloro-2-methylbenzene)sulfonyl]-
N-cyclohexylpiperidine-3-carboxamide | [Molecular Formula]
C19H27ClN2O3S | [MDL Number]
MFCD11226407 | [MOL File]
872506-67-7.mol | [Molecular Weight]
398.95 |
| Hazard Information | Back Directory | [Description]
INCB13739 is a potent, selective, oral 11βHSD1 inhibitor (IC50=1.1 nM) for the treatment of type 2 diabetes. INCB-13739 has high selectivity for 11beta-HSD1 over other dehydrogenases and glucocorticoid and mineralocorticoid receptors, with prolonged pharmacodynamic activity and good pharmacokinetic/pharmacodynamic properties. INCB-13739 demonstrated improved hepatic and peripheral insulin sensitivity with a satisfactory reduction in fasting plasma glucose and cholesterol | [Uses]
11β-HSD1-IN-12 is a 11β-HSD1 inhibitor (Example 21 in reference patent). 11β-HSD1 regenerates active glucocorticoids from inactive forms and is important in regulating intracellular glucocorticoid concentration. 11β-HSD1-IN-12 can be used in the research of obesity and metabolic syndrome[1]. | [References]
[1] Wenqing Yao, et al. N-substituted piperidines and their use as pharrmaceuticals. Patent. US20060004049A1. |
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| Company Name: |
DC Chemicals
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021-58447131 13564518121 |
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http://m.is0513.com/ShowSupplierProductsList927327/0.htm |
| Company Name: |
EvoBlocks, Ltd.
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+36 (20) 5757-305 |
| Website: |
www.evoblocks.com |
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