| Identification | Back Directory | [Name]
3'-azido-2',3'-dideoxy-5-methylcytidine | [CAS]
87190-79-2 | [Synonyms]
CS-92
AzddMeC
3'-azido-2',3'-dideoxy-5-methylcytidine
3'-Azido-2',3'-dideoxy-4-deoxo-4-imino-5-methyluridine | [Molecular Formula]
C10H14N6O3 | [MOL File]
87190-79-2.mol | [Molecular Weight]
266.26 |
| Chemical Properties | Back Directory | [storage temp. ]
4°C, away from moisture | [solubility ]
DMSO : 200 mg/mL (751.15 mM; Need ultrasonic) | [form ]
Solid | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
AzddMeC is used as an antiviral agent for treating viral infection. | [in vivo]
The pharmacokinetics of AzddMeC are characterized following intravenous and oral administration of 60 mg/kg of the compound to male rhesus monkeys. 3'-azido-3'-deoxythymidine (AZT) is a major metabolite of AzddMeC in monkeys. AzddMeC concentrations in serum declined rapidly in a biexponential fashion with the terminal half-life ranging from 0.5 to 1.3 hr. Renal excretion of unchanged nucleoside and metabolic deamination yielding AZT are the primary routes of AzddMeC clearance. The oral bioavailability is 26%[2]. | [IC 50]
HIV-2; HIV-1: 9 nM (EC50, Human PBM cells); HIV-1: 6 nM (EC50, Human macrophages) | [storage]
4°C, away from moisture |
|
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BOC Sciences
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1-631-485-4226; 16314854226 |
| Website: |
https://www.bocsci.com |
| Company Name: |
MedChemExpress
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021-58955995 |
| Website: |
www.medchemexpress.com |
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