| Identification | Back Directory | [Name]
Bamaluzole | [CAS]
87034-87-5 | [Synonyms]
Bamaluzole
4-(2-chlorobenzyloxy)-1-methyl-1H-imidazo[4,5-c]pyridine
1H-Imidazo[4,5-c]pyridine, 4-[(2-chlorophenyl)methoxy]-1-methyl- | [Molecular Formula]
C14H12ClN3O | [MDL Number]
MFCD00868674 | [MOL File]
87034-87-5.mol | [Molecular Weight]
273.72 |
| Hazard Information | Back Directory | [Originator]
Bamaluzole,Onbio Inc. | [Uses]
Bamaluzole, is a GABA receptor agonist. | [Manufacturing Process]
1-Chlorophenyl-2-methanol is dissolved in dimethylformamide; NaH is added
and the mixture is stirred at 20°C for 1 h. After a solution of 4-chloro-1-
methyl-1H-imidazo[4,5-c]pyridine [melting point 132°-134°C; obtainable by
reaction of 4-methylamino-3-nitropyridine with HCl/SnCl2 to give 3-amino-2-
chloro-4-methylaminopyridine (melting point 170°-173°C) and reaction with
HCOOH/acetic anhydride] in dimethylformamide has been added, the mixture
is stirred at 90°-95°C for 15 h. The mixture is evaporated and the residue is
worked up in the customary manner to give 4-o-chlorobenzyloxy-1-methyl-
1H-imidazo[4,5-c]pyridine, melting point 132°-135°C (crystallize from ethyl
acetate-tetrahydofuran). | [Therapeutic Function]
Anticonvulsant | [storage]
Store at -20°C |
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