| Identification | Back Directory | [Name]
N-[4-(2-BROMO-4,5-DIFLUOROPHENOXY)PHENYL]-L-ASPARAGINE | [CAS]
868359-05-1 | [Synonyms]
WAY 213613
N-[4-(2-BROMO-4,5-DIFLUOROPHENOXY)PHENYL]-L-ASPARAGINE
N4-[4-(2-Bromo-4,5-difluorophenoxy)phenyl)]-L-asparagine
L-Asparagine, N-[4-(2-bromo-4,5-difluorophenoxy)phenyl]- | [Molecular Formula]
C16H13BrF2N2O4 | [MDL Number]
MFCD09971111 | [MOL File]
868359-05-1.mol | [Molecular Weight]
415.19 |
| Chemical Properties | Back Directory | [Boiling point ]
565.6±50.0 °C(Predicted) | [density ]
1.664±0.06 g/cm3(Predicted) | [storage temp. ]
Desiccate at RT | [solubility ]
DMSO: >10mg/mL | [form ]
white powder | [pka]
2.38±0.10(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
WAY 213613 is a selective non-substrate inhibitor of EAAT2. It is used in the methods of treating or inhibiting onset of Huntington''s disease with gene modulatory compounds. | [Biological Activity]
Potent, non-substrate inhibitor of EAAT2 (GLT-1) that displays > 44-fold selectivity over EAAT1 and EAAT3 (IC 50 values are 85, 3787 and 5004 nM for EAAT2, EAAT3 and EAAT1 respectively). Exhibits no activity towards ionotropic and metabotropic glutamate receptors. | [storage]
Desiccate at RT |
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