| Chemical Properties | Back Directory | [density ]
1.36±0.1 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [form ]
Solid | [pka]
7.06±0.40(Predicted) | [color ]
Off-white to light yellow |
| Hazard Information | Back Directory | [Uses]
ONO 5334 is a novel cathepsin K inhibitor. Inhibited bone resorption in human osteoclast and reduced calcium level increased by PTHrP in thyroparathyroidectomized rat and decreased serum and urine C-telopeptide of type I collagen level in monkey. Values in postmenopausal patient with osteoporosis, increases lumbar spine, total hip and femoral neck bone minerals. | [in vivo]
ONO-5334 (oral administration; 0.12-15 mg/kg; single dose) can dose-dependently reduce PTHrP-induced increase in plasma calcium with significant effect (86% reduction) at 15 mg/kg. It also reduces PTHrP-induced increase in plasma CTX level in TPTX rats by 90% at 15 mg/kg[1].ONO-5334 (oral administration; 0.3-30 mg/kg; 7 consecutive days) at 3 mg/kg or 30 mg/kg significantly decreases CTX (a bone resorption marker) concentration. On day 7, the reduction in serum CTX concentration by ONO-5334 at 3 mg/kg and 30 mg/kg was 62% and 79%, respectively[1]. | Animal Model: | Monkey[1] | | Dosage: | 0.3 mg/kg; 3 mg/kg | | Administration: | Oral administration; 7 consecutive days | | Result: | Reduced bone resorption markers but not bone formation markers in normal monkeys. |
| [IC 50]
cathepsin K |
|
| Company Name: |
MedChemExpress
|
| Tel: |
021-58955995 |
| Website: |
www.medchemexpress.com |
|