| Identification | Back Directory | [Name]
Phenol, 4-chloro-3-[5-Methyl-3-[[4-[2-(1-pyrrolidinyl)ethoxy]phenyl]aMino]-1,2,4-benzotriazin-7-yl]- | [CAS]
867334-05-2 | [Synonyms]
TG 100572
TG100572;TG-100572
4-Chloro-3-[5-methyl-3-[[4-[2-(1-pyrrolidinyl)ethoxy]phenyl]amino]-1,2,4-benzotriazin-7-yl]phenol
4-Chloro-3-(5-methyl-3-(4-(2-(pyrrolidin-1-yl)ethoxy)phenylamino)benzo[e][1,2,4]triazin-7-yl)phenol
Phenol, 4-chloro-3-[5-Methyl-3-[[4-[2-(1-pyrrolidinyl)ethoxy]phenyl]aMino]-1,2,4-benzotriazin-7-yl]- | [Molecular Formula]
C26H26ClN5O2 | [MDL Number]
MFCD16877427 | [MOL File]
867334-05-2.mol | [Molecular Weight]
475.97 |
| Chemical Properties | Back Directory | [Boiling point ]
683.5±65.0 °C(Predicted) | [density ]
1.331±0.06 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
DMSO: ≥ 150 mg/mL (315.15 mM) | [form ]
Powder | [pka]
8.82±0.18(Predicted) |
| Hazard Information | Back Directory | [Uses]
TG 100572 is a Src kinase inhibitor. | [in vivo]
Systemic delivery of TG 100572 in a murine model of laser-induced choroidal neovascularization (CNV) causes significant suppression of CNV, but with an associated weight loss suggestive of systemic toxicity[1]. A concentration of 23.4 μM (Cmax) of TG 100572 is reached in 30 min (Tmax)=0.5 h) in the choroid and the sclera. However, the levels of TG 100572 in the retina are relatively low. The half-life of TG 100572 in ocular tissues is very short; hence, the compound is administered topically minimum t.i.d. to maintain appropriate drug levels in the eye. The maximum concentration one can achieve in formulations using TG 100572 is 0.7% w/v[2]. | [IC 50]
VEGFR1: 2 nM (IC50); VEGFR2: 7 nM (IC50); FGFR1: 2 nM (IC50); FGFR2: 16 nM (IC50); PDGFRβ: 13 nM (IC50) |
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SPIRO PHARMA
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www.spiropharma.com.cn |
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Musechem
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DC Chemicals
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https://www.weikeqi-biotech.com/ |
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