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ChemicalBook--->CAS DataBase List--->86727-00-6

86727-00-6

86727-00-6 Structure

86727-00-6 Structure
IdentificationBack Directory
[Name]

CK 17
[CAS]

86727-00-6
[Synonyms]

CK 17
[Molecular Formula]

C17H15BrN2OS
[MDL Number]

MFCD00918905
[MOL File]

86727-00-6.mol
[Molecular Weight]

375.289
Chemical PropertiesBack Directory
[Melting point ]

103-104 °C(Solv: ethanol (64-17-5))
[Boiling point ]

470.0±55.0 °C(Predicted)
[density ]

1.41±0.1 g/cm3(Predicted)
[pka]

-2.31±0.40(Predicted)
Hazard InformationBack Directory
[Description]

CK 17 is a interleukin-1 antagonist. It is a IL-1 blocker that suppresses fibroblast proliferation in a concentration-dependent manner.
[Uses]

CK-17 is an orally active and potent anti-inflammatory agent. CK-17 shows potent inhibition of ocular inflammation induced by lens protein, endotoxin, and IL-1. The effects on IL-1-induced inflammation are about 2 fold more potent than Prednisolone (HY-17463)[1].
[References]

[1] Chiou GC, et al. Prevention of ocular inflammation induced by lens protein, endotoxin, and interleukin-1 with synthetic interleukin-1 blockers. J Ocul Pharmacol. 1994 Fall;10(3):577-86. DOI:10.1089/jop.1994.10.577
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