| Identification | Back Directory | [Name]
ERAP1-IN-1 | [CAS]
865273-97-8 | [Synonyms]
ERAP1-IN-1
Benzoic acid, 4-methoxy-3-[[[2-(1-piperidinyl)-5-(trifluoromethyl)phenyl]amino]sulfonyl]- | [Molecular Formula]
C20H21F3N2O5S | [MDL Number]
MFCD07309764 | [MOL File]
865273-97-8.mol | [Molecular Weight]
458.45 |
| Chemical Properties | Back Directory | [Boiling point ]
605.6±65.0 °C(Predicted) | [density ]
1.428±0.06 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
DMSO: 250 mg/mL (545.32 mM) | [form ]
Solid | [pka]
3.88±0.10(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Biological Activity]
ERAP1-in-1 is an inhibitor of endoplasmic reticulum aminopeptidase 1 (ERAP1), which competitively inhibits the action of ERAP1 on representative biological substrates nonamer peptides. | [in vitro]
ERAP1-IN-1 (compound 3) allosterically activates ERAP1's hydrolysis of fluorogenic and chromogenic amino acid substratesv.
ERAP1-IN-1 (50 μM) exhibits specific inhibition of ERAP1 in the cellular context.
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