| Identification | Back Directory | [Name]
Ecabet sodium | [CAS]
86408-72-2 | [Synonyms]
ta-2711
Gastrom
TA-2711E
ECABET SODIUM
Ecabetsodiumsalt
1), (1R,4aS,10aR)-
ECABET SODIUM,99+%
12-sulfodehydroabieticacidmonosodiumsalt
sulfodehydroabieticacidmonosodiumsaltusxxam#4529602
(1r-(1-alpha,4a-beta,10a-alpha))--methylethyl)-6-sulfomonosodiumsalt
1-Phenanthrenecarboxylicacid, 1,2,3,4,4a,9,10,10a-octahydro-1,4a-diMethyl-7-(1-Methylethyl)-6-sulfo-,sodiuM salt (1
1-Phenanthrenecarboxylic acid, 1,2,3,4,4a,9,10,10a-octahydro-1,4a-dimethyl-7-(1-methylethyl)-6-sulfo-, monosodium salt, (1R,4aS,10aR)-
1-Phenanthrenecarboxylic acid, 1,2,3,4,4a,9,10,10a-octahydro-1,4a-dimethyl-7-(1-methylethyl)-6-sulfo-,sodium salt (1:1),(1R,4aS,10aR)-
1-Phenanthrenecarboxylic acid, 1,2,3,4,4a,9,10,10a-octahydro-1,4a-dimethyl-7-(1-methylethyl)-6-sulfo-, monosodium salt, [1R-(1α,4aβ,10aα)]-
(1r-(1-alpha,4a-beta,10a-alpha))-1,2,3,4,4a,9,10,10a-octahydro-1,4a-dimethyl-7-(1-methylethyl)-6-sulfo-1-phenanthrenecarboxylic acid sodium salt | [EINECS(EC#)]
1312995-182-4 | [Molecular Formula]
C20H27NaO5S | [MDL Number]
MFCD00866896 | [MOL File]
86408-72-2.mol | [Molecular Weight]
402.48 |
| Chemical Properties | Back Directory | [Melting point ]
>300° | [alpha ]
D20 +59.4° (c = 0.5) | [storage temp. ]
Store at -20°C | [solubility ]
DMF: 25 mg/ml; DMSO: 30 mg/ml; Ethanol: 3 mg/ml; PBS (pH 7.2): 3 mg/ml | [form ]
A crystalline solid | [color ]
White to off-white |
| Hazard Information | Back Directory | [Description]
Ecabet sodium is a new antiulcer agent launched in Japan for the treatment of gastric
ulcer. It has both mucosal-protective and tissue-repairing properties. In rats, it effectively
prevents gastrointestinal lesion formation induced experimentally by EtOH, HCl, NaOH, and
boiling water. The mechanism of action has been suggested to involve inhibition of pepsin
activity in gastric juice by precipitating pepsin in the form of a complex and inactivating
pepsinogen. | [Originator]
Tanabe (Japan) | [Uses]
Ecabet sodium (TA-2711) is currently applied to some gastrointestinal disease by inhibiting the ROS production and improving Helicobacter pylori eradication[1]. Ecabet sodium reduces apoptosis[2]. | [Brand name]
Gastrom | [References]
[1] Wang Y, et al. Efficacy and safety of ecabet sodium as an adjuvant therapy for Helicobacter pylori eradication: a systematic review and meta-analysis. Helicobacter. 2014 Oct;19(5):372-81. DOI:10.1111/hel.12136
[2] Rah YC, et al. Ecabet sodium alleviates neomycin-induced hair cell damage. Free Radic Biol Med. 2015 Dec;89:1176-83. DOI:10.1016/j.freeradbiomed.2015.11.007
[3] Kenji Kusumoto, et al. Ecabet sodium inhibits Helicobacter pylori lipopolysaccharide-induced activation of NADPH oxidase 1 or apoptosis of guinea pig gastric mucosal cells. Am J Physiol Gastrointest Liver Physiol DOI:10.1152/ajpgi.00274.2004 |
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