| Identification | Back Directory | [Name]
4-{[(1,3-benzothiazol-2-ylsulfanyl)acetyl]amino}benzoic acid | [CAS]
86109-60-6 | [Synonyms]
PTP1BIN22
WYE-176244
PTP1B-IN-22
4-(2-(Benzo[d]thiazol-2-ylthio)acetamido)benzoic acid
Benzoic acid, 4-[[2-(2-benzothiazolylthio)acetyl]amino]-
4-{[(1,3-benzothiazol-2-ylsulfanyl)acetyl]amino}benzoic acid | [Molecular Formula]
C16H12N2O3S2 | [MDL Number]
MFCD00396380 | [MOL File]
86109-60-6.mol | [Molecular Weight]
344.41 |
| Chemical Properties | Back Directory | [Melting point ]
218-219 °C(Solv: ethanol (64-17-5)) | [density ]
1.50±0.1 g/cm3(Predicted) | [form ]
Solid | [pka]
4.25±0.10(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
PTP1B-IN-22, a ZINC02765569 derivative, is a potent protein tyrosine phosphatase 1B (PTP1B) inhibitor. PTP1B-IN-22 has PTP1B inhibition and glucose uptake in skeletal muscle L6 myotubes[1]. | [References]
[1] Prashant J, et, al. Molecular modeling and synthesis of ZINC02765569 derivatives as protein tyrosine phosphatase 1B inhibitors: lead optimization study. 2012;22: 1618-23. |
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Merck KGaA
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(+86) 21 2033 8288 |
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http://www.sigmaaldrich.cn |
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