| Identification | Back Directory | [Name]
AGN 205728 | [CAS]
859498-05-8 | [Synonyms]
CS-1209
AGN 205728
Benzoic acid, 4-[(1E,3E)-3-[7,8-dihydro-8,8-dimethyl-5-(4-methylphenyl)-2-naphthalenyl]-3-(hydroxyimino)-1-propen-1-yl]- | [Molecular Formula]
C29H27NO3 | [MDL Number]
MFCD28167795 | [MOL File]
859498-05-8.mol | [Molecular Weight]
437.53 |
| Chemical Properties | Back Directory | [Boiling point ]
636.2±55.0 °C(Predicted) | [density ]
1.13±0.1 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc. | [form ]
Powder | [pka]
4.14±0.10(Predicted) | [color ]
Light yellow to khaki |
| Hazard Information | Back Directory | [Uses]
AGN 205728 is a potent and selective RARγ antagonist with Ki/IC95 values of 3 nM/ 0.6 nM; no inhibiton on RARα and RARβ.
IC50 value: 3 nM/ 0.6 nM(Ki/IC95)
Target: RARγ antagonist
More information can be found in the following patent, Compound 7a.
Preparation of disubstituted chalcone oximes having RARγ retinoid receptor antagonist activity
By Tsang, Kwok Yin; Sinha, Santosh; Liu, Xiaoxia; Bhat, Smita; Chandraratna, Roshantha A.
From PCT Int. Appl. (2005), WO 2005066115 A2 20050721. | [References]
[1] Tsang, Kwok Yin, et al. Preparation of disubstituted chalcone oximes having RARγ retinoid receptor antagonist activity. Appl. (2005), WO 2005066115 A2 20050721. |
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