Identification | Back Directory | [Name]
MDL 72274A | [CAS]
85278-24-6 | [Synonyms]
MDL 72274A MDL72274 HCl Beta-(Chloromethylene)benzeneethanamine hydrochloride (E)-beta-(Chloromethylene)benzeneethanamine hydrochloride MDL72274; MDL-72274; MDL 72274; MDL72274A; MDL-72274A; MDL 72274A; MDL72274 HCL | [Molecular Formula]
C9H11Cl2N | [MDL Number]
MFCD29058563 | [MOL File]
85278-24-6.mol | [Molecular Weight]
204.09 |
Hazard Information | Back Directory | [Description]
MDL-72274 HCl is selective and potent inhibitors of SSAO for treatment of Parkinson diseases. MDL-72974 is a potent (IC50 = 10(-9) M) inhibitor of both MAO-B and SSAO, with 190-fold lower affinity for MAO-A. In clinical studies, oral doses as low as 100 micrograms produced substantial inhibition of platelet MAO-B. One or 4 mg MDL-72274 HCl given daily for 28 days to 40 Parkinson's patients treated with L-dopa produced statistically significant reductions in the Unified Parkinson's Disease Rating Scale. MAO-B inhibitors, such as MDL 72974A and L-deprenyl, offer the potential of being neuroprotective in Parkinson's Disease and other neurogenerative disorders. |
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Company Name: |
AstaTech, Inc
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Tel: |
(215) 785 3197 |
Website: |
www.astatechinc.com |
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