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ChemicalBook--->CAS DataBase List--->85278-24-6

85278-24-6

85278-24-6 Structure

85278-24-6 Structure
IdentificationBack Directory
[Name]

MDL 72274A
[CAS]

85278-24-6
[Synonyms]

MDL 72274A
MDL72274 HCl
Beta-(Chloromethylene)benzeneethanamine hydrochloride
(E)-beta-(Chloromethylene)benzeneethanamine hydrochloride
MDL72274; MDL-72274; MDL 72274; MDL72274A; MDL-72274A; MDL 72274A; MDL72274 HCL
[Molecular Formula]

C9H11Cl2N
[MDL Number]

MFCD29058563
[MOL File]

85278-24-6.mol
[Molecular Weight]

204.09
Hazard InformationBack Directory
[Description]

MDL-72274 HCl is selective and potent inhibitors of SSAO for treatment of Parkinson diseases. MDL-72974 is a potent (IC50 = 10(-9) M) inhibitor of both MAO-B and SSAO, with 190-fold lower affinity for MAO-A. In clinical studies, oral doses as low as 100 micrograms produced substantial inhibition of platelet MAO-B. One or 4 mg MDL-72274 HCl given daily for 28 days to 40 Parkinson's patients treated with L-dopa produced statistically significant reductions in the Unified Parkinson's Disease Rating Scale. MAO-B inhibitors, such as MDL 72974A and L-deprenyl, offer the potential of being neuroprotective in Parkinson's Disease and other neurogenerative disorders.
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