| Identification | Back Directory | [Name]
MK-0812 (Succinate) | [CAS]
851916-42-2 | [Synonyms]
MK-0812 HCL
MK-0812 (Succinate)
MK 0812 SUCCINATE;MK0812 SUCCINATE | [Molecular Formula]
C28H40F3N3O7 | [MDL Number]
MFCD30489753 | [MOL File]
851916-42-2.mol | [Molecular Weight]
587.64 |
| Hazard Information | Back Directory | [Description]
MK0812 Succinate is a dual CCR2-CCR5 receptor antagonist. | [Uses]
MK-0812 Succinate is a potent and selective CCR2 antagonist with high affinity at CCR2. | [in vivo]
MK-0812 (30 mg/kg, p.o.) reduces the frequency of Ly6G-Ly6Chi monocytes in the peripheral blood, while no impact on circulating Ly6G+Ly6C+ neutrophil frequency is observed. In addition, MK-0812 treatment causes a dose-dependent reduction in circulating Ly6Chi monocytes and a corresponding elevation in the CCR2 ligand CCL2[1]. MK-0812 is administered by continuous i.v. infusion to maintain a constant level of the drug in blood[2]. | [IC 50]
CCR2 | [storage]
Store at -20°C | [References]
[1] Min SH, et al. Pharmacological targeting reveals distinct roles for CXCR2/CXCR1 and CCR2 in a mouse model of arthritis.Biochem Biophys Res Commun. 2010 Jan 1;391(1):1080-6. DOI:10.1016/j.bbrc.2009.12.025
[2] Wisniewski T, et al. Assessment of chemokine receptor function on monocytes in whole blood: In vitro and ex vivo evaluations of a CCR2 antagonist.J Immunol Methods. 2010 Jan 31;352(1-2):101-10. DOI:10.1016/j.jim.2009.10.010 |
|
| Company Name: |
Musechem
|
| Tel: |
+1-800-259-7612 |
| Website: |
www.musechem.com |
| Company Name: |
Twochem Co.Ltd.
|
| Tel: |
021-58111628 15800915896 |
| Website: |
cn.twochem.com |
| Company Name: |
DC Chemicals
|
| Tel: |
021-58447131 13564518121 |
| Website: |
http://m.is0513.com/ShowSupplierProductsList927327/0.htm |
| Company Name: |
InvivoChem
|
| Tel: |
13549236410 |
| Website: |
https://www.invivochem.cn/ |
|