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ChemicalBook--->CAS DataBase List--->848695-25-0

848695-25-0

848695-25-0 Structure

848695-25-0 Structure
IdentificationBack Directory
[Name]

BIIB-021
[CAS]

848695-25-0
[Synonyms]

CS-479
CNF2024
BIIB-021
CNF-2024EC102
BIIB021/CNF2024
BIIB-021 USP/EP/BP
CNF 2024 - BIIB 021
BIIB021(CNF2024)BIIB021
BIIB021;BIIB-021; BIIB 021
CNF2024; BIIB-021; BIIB 021; CNF 2024; CNF-2024
BIIB 021 (This product is only available in Japan.)
6-CHLORO-9-[(4-METHOXY-3,5-DIMETHYLPYRIDIN-2-YL)METHYL]PURIN-2-AMINE
6-Chloro-9-[(4-methoxy-3,5-dimethyl-2-pyridinyl)methyl]-9H-purin-2-amine
6-chloro-9-((4-Methoxy-3,5-diMethylpyridin-2-yl)Methyl)-9H-purin-2-aMine
9H-Purin-2-aMine, 6-chloro-9-[(4-Methoxy-3,5-diMethyl-2-pyridinyl)Methyl]-
9-[2-(2,2-diMethyl-propylaMino)ethyl]-8-(2-iodo-5-Methoxy-phenylsulfanyl)-9H-purin-6-ylaMine
6-Chloro-9-[(4-methoxy-3,5-dimethyl-2-pyridinyl)methyl]-9H-purin-2-amine BIIB 021
BIIB 021 6-Chloro-9-[(4-methoxy-3,5-dimethyl-2-pyridinyl)methyl]-9H-purin-2-amine
[EINECS(EC#)]

812-781-2
[Molecular Formula]

C14H15ClN6O
[MDL Number]

MFCD15528939
[MOL File]

848695-25-0.mol
[Molecular Weight]

318.76
Chemical PropertiesBack Directory
[Melting point ]

192-193℃
[Boiling point ]

588.5±60.0 °C(Predicted)
[density ]

1.50
[storage temp. ]

-20°C
[solubility ]

Soluble in DMSO (>25 mg/ml)
[form ]

solid
[pka]

6.07±0.40(Predicted)
[color ]

White
[Stability:]

Stable for 1 year as supplied. Solutions in DMSO may be stored at -20°C for up to 3 montha.
Safety DataBack Directory
[HS Code ]

2921490090
Hazard InformationBack Directory
[Description]

BIIB021 is a potent HSP90 inhibitor (IC50 = 30 nM HER-2 degradation).1 It inhibited the proliferation of MCF7 and BT474 breast cancer cell lines (IC50 = 100 nM for each).? BIIB021 has shown efficacy as a therapeutic in multiple cancer models.2-5
[Uses]

BIIB 021 an orally available, fully synthetic small-molecule inhibitor of the heat shock protein Hsp90. Studies show that BIIB 021 adminisitration led to degradation of Hsp90 client proteins measured in tumor tissue and resulted in the inhibition of tumor growth in several human tumor xenograft models.
[Definition]

ChEBI: A member of the class of 2-aminopurines that is 2-aminopurine which is substituted by a chlorine at position 6 and by a (4-methoxy-3,5-dimethylpyridin-2-yl)methyl group at position 9.
[References]

Kasibhatla et al. (2007), Rationally designed high-affinity 2-amino-6-halopurine heat shock protein 90 inhibitors that exhibit potent antitumor activity; J. Med. Chem. 50 2767 Lundgren et al. (2009), BIIB021, an orally available, fully synthetic small-molecule inhibitor of the heat shock protein Hsp90; Mol. Cancer Ther. 8 921 Boll et al. (2009), Heat shock protein 90 inhibitor BIIB021 (CNF2024) depletes NF-kappaB and sensitizes Hodgkin’s lymphoma cells for natural killer cell-mediated cytotoxicity; Clin. Cancer Res. 15 5108 Zhang et al. (2010), BIIB021, a synthetic Hsp90 inhibitor, has broad application against tumors with acquired multidrug resistance; Int. J. Cancer 126 1226 Wang et al. (2014), BIIB021, a novel Hsp90 inhibitor, sensitizes esophageal squamous cell carcinoma to radiation; Biochem. Biophys. Res. Commun. 452 945
Spectrum DetailBack Directory
[Spectrum Detail]

BIIB-021(848695-25-0)1HNMR
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