| Identification | Back Directory | [Name]
IFN alpha-IFNAR-IN-1 | [CAS]
844882-93-5 | [Synonyms]
IFNAR-IN-1
IFN alpha-IFR-IN-1
IFN alpha-IFNAR-IN-1
Benzenemethanamine, N-methyl-2-(1-naphthalenylthio)-
IFNAR-IN-1
(IFN-alpha and IFNAR interaction inhibitor) | [Molecular Formula]
C18H17NS | [MDL Number]
MFCD04108079 | [MOL File]
844882-93-5.mol | [Molecular Weight]
279.4 |
| Chemical Properties | Back Directory | [Boiling point ]
419.4±28.0 °C(Predicted) | [density ]
1.17±0.1 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
Soluble in DMSO | [pka]
9.31±0.10(Predicted) |
| Hazard Information | Back Directory | [Uses]
IFN alpha-IFNAR-IN-1 is a nonpeptidic, low-molecular-weight inhibitor of the interaction between IFN-α and IFNAR; inhibit MVA-induced IFN-α responses by BM-pDCs (IC50=2-8 uM).
IC50 value:
Target: IFN alpha-IFNAR interaction inhibitor
IFN alpha-IFNAR-IN-1 specifically inhibits MVA-induced IFN-α responses by BM-pDCs. IFN alpha-IFNAR-IN-1 inhibited the IFN-α responses that were elicited after treatment with CpG2216, stimulation with poly(I:C), and infection with VSV-M2, whereas the total IL-12 production was notably less affected under those conditions. IFN alpha-IFNAR-IN-1 exerts immunosuppressive activity by the direct interaction with IFN-α [1]. | [storage]
Store at -20°C | [References]
[1] Geppert T, et al. Immunosuppressive small molecule discovered by structure-based virtual screening for inhibitors of protein-protein interactions. Angew Chem Int Ed Engl. 2012 Jan 2;51(1):258-61. DOI:10.1002/anie.201105901 |
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| Company Name: |
Musechem
|
| Tel: |
+1-800-259-7612 |
| Website: |
www.musechem.com |
| Company Name: |
cuicheng bio
|
| Tel: |
13186333400 |
| Website: |
www.cuichengbio.com/ |
|