| Identification | Back Directory | [Name]
bucolome | [CAS]
841-73-6 | [Synonyms]
Bucolom
bucolome
Paramidin
Butymidin
Paramidine
bucolome USP/EP/BP
Bucolomum [INN-Latin]
5-Butyl-1-cyclohexylbarbituric acid
5-n-Butyl-1-cyclohexylbarbituric acid
5-butyl-1-cyclohexyl-1,3-diazinane-2,4,6-trione
Barbituric acid, 5-butyl-1-cyclohexyl- (7CI, 8CI)
5-Butyl-1-cyclohexyl-2,4,6-trioxoperhydropyrimidine
1-Cyclohexyl-5-butyl-2,4,6-trioxoperhydropyrimidine
5-Butyl-1-cyclohexyl-2,4,6-trioxoperhydroxyprimidine
5-n-Butyl-1-cyclohexyl-2,4,6-trioxoperhydropyrimidine
5-Butyl-1-cyclohexyl-2,4,6(1H,3H,5H)-pyrimidinetrione
2,4,6(1H,3H,5H)-Pyrimidinetrione, 5-butyl-1-cyclohexyl- | [EINECS(EC#)]
212-666-1 | [Molecular Formula]
C14H22N2O3 | [MDL Number]
MFCD00866109 | [MOL File]
841-73-6.mol | [Molecular Weight]
266.34 |
| Chemical Properties | Back Directory | [Melting point ]
84° | [Boiling point ]
bp0.8 185-187° | [density ]
1.0807 (rough estimate) | [refractive index ]
1.5110 (estimate) | [form ]
Solid | [pka]
5.71±0.40(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
Bucolome is a CYP2C9 inhibitor, used as an uricosuric agent or anti-inflammatory agent. | [Definition]
ChEBI: 5-butyl-1-cyclohexylbarbituric acid is a member of barbiturates. | [IC 50]
CYP2 | [References]
[1] Takahashi H, et al. Pharmacokinetic interaction between warfarin and a uricosuric agent, bucolome: application of In vitro approaches to predicting In vivo reduction of (S)-warfarin clearance. Drug Metab Dispos. 1999 Oct;27(10):1179-86. PMID:10497145 |
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