| Identification | Back Directory | [Name]
Spirapril | [CAS]
83647-97-6 | [Synonyms]
SPIRAPRIL
Sandopfil
Sch-33844
Espirapril
Brn 4277924
Spiraprilum
Spiraprilic acid
Spiraprilum [latin]
Spirapril [inn:ban]
Espirapril [spanish]
SPIRAPRIL FOR SYSTEM SUITABILITY EPY
SPIRAPRIL FOR SYSTEM SUITABILITY EPY(CRM STANDARD)
(8S-(7(R*(R*)),8R*))-7-(2-((1-(Ethoxycarbonyl)-3-phenylpropyl)amino)-1-oxopropyl)-1,4-dithia-7-azaspiro[4.4]nonane-8-carboxylic acid
1,4-Dithia-7-azaspiro(4,4)nonane-8-carboxylic acid, 7-(2-((1-(ethoxycarbonyl)-3-phenylpropyl)amino)-1-oxopropyl)-, (8S-(7(R*(R*)),8R*))- | [Molecular Formula]
C22H30N2O5S2 | [MDL Number]
MFCD00865789 | [MOL File]
83647-97-6.mol | [Molecular Weight]
466.61 |
| Hazard Information | Back Directory | [Uses]
Spirapril is an Angiotensin-converting enzyme inhibitor and used to treat high blood pressure. | [Definition]
ChEBI: Spirapril is a dipeptide, a dithioketal, an azaspiro compound, a dicarboxylic acid monoester, an ethyl ester, a tertiary carboxamide, a secondary amino compound and a pyrrolidinecarboxylic acid. It has a role as a prodrug, an EC 3.4.15.1 (peptidyl-dipeptidase A) inhibitor and an antihypertensive agent. It is functionally related to a spiraprilat. | [in vivo]
Spirapril (feeding needle; 10 mg/kg; 3 weeks) decreases alcohol intake in TGM123 mice and dose not reduce the alcohol consumption in TLM mice[2].
Spirapril shows a 40.2% reduction in ACE activity in brain membrane from treated-mice[2].
Spirapril can crosses the blood-brain barrier and suppresses the transgene effect in the experiments[2].
Spirapril prevents left ventricular hypertrophy, decreases myocardial damage and promotes angiogenesis in spontaneously hypertensive rats[3]. |
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