| Identification | Back Directory | [Name]
1H-Isoindole-1,3(2H)-dione, 2-(2,6-dioxo-3-piperidinyl)-5-fluoro- | [CAS]
835616-61-0 | [Synonyms]
135588
Thalidomide 5-fluoride
Light purple to off white powder
2-(2,6-dioxopiperidin-3-yl)-5-fluoroisoindole-1,3-dione
2-(2,6-dioxopiperidin-3-yl)-5-fluoroisoindoline-1,3-dione
? 2-(2,6-Dioxopiperidin-3-yl)-5- difluoroisoindoline-1,3-dione
2-(2,6-Dioxo-3-piperidinyl)-5-fluoro-1H-isoindole-1,3(2H)-dione
1H-Isoindole-1,3(2H)-dione, 2-(2,6-dioxo-3-piperidinyl)-5-fluoro- | [Molecular Formula]
C13H9FN2O4 | [MDL Number]
MFCD30188075 | [MOL File]
835616-61-0.mol | [Molecular Weight]
276.22 |
| Chemical Properties | Back Directory | [Boiling point ]
521.5±45.0 °C(Predicted) | [density ]
1.570±0.06 g/cm3(Predicted) | [storage temp. ]
Inert atmosphere,Room Temperature | [solubility ]
DMSO: 83.33 mg/mL (301.68 mM) | [form ]
Solid | [pka]
10.65±0.40(Predicted) | [color ]
Off-white to gray | [InChI]
InChI=1S/C13H9FN2O4/c14-6-1-2-7-8(5-6)13(20)16(12(7)19)9-3-4-10(17)15-11(9)18/h1-2,5,9H,3-4H2,(H,15,17,18) | [InChIKey]
MPQLCQKBYRSPNA-UHFFFAOYSA-N | [SMILES]
C1(=O)C2=C(C=C(F)C=C2)C(=O)N1C1CCC(=O)NC1=O |
| Hazard Information | Back Directory | [Description]
2-(2,6-dioxopiperidin-3-yl)-5-fluoroisoindoline-1,3-dione is a thalidomide analog that can be useful in PROTAC research. | [Uses]
Thalidomide 5'- fluoro (2-(2,6-Dioxopiperidin-3-yl)-5-fluoroisoindoline-1,3-dione) is a derivative of Thalidomide, commonly used as a precursor to PROTAC® Degraders that hijacks cereblon as the E3 ubiquitin ligase component. Supplied with a fluoro functional handle at a position known not to significantly affect binding to cereblon, ready for conjugation to a linker/target protein ligand.
| [IC 50]
Cereblon | [storage]
Store at +4°C |
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