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ChemicalBook--->CAS DataBase List--->835598-94-2

835598-94-2

835598-94-2 Structure

835598-94-2 Structure
IdentificationBack Directory
[Name]

GLX351322
[CAS]

835598-94-2
[Synonyms]

CS-2871
GLX 351322;GLX-351322
4H-Cyclopenta[b]thiophene-3-carboxylic acid, 2-[[2-[4-(2-furanylcarbonyl)-1-piperazinyl]acetyl]amino]-5,6-dihydro-, ethyl ester
[Molecular Formula]

C21H25N3O5S
[MDL Number]

MFCD05123600
[MOL File]

835598-94-2.mol
[Molecular Weight]

431.51
Chemical PropertiesBack Directory
[solubility ]

DMSO:20.0(Max Conc. mg/mL);46.35(Max Conc. mM)
DMF:1.0(Max Conc. mg/mL);2.32(Max Conc. mM)
DMF:PBS (pH 7.2) (1:2):0.33(Max Conc. mg/mL);0.76(Max Conc. mM)
Ethanol:4.0(Max Conc. mg/mL);9.27(Max Conc. mM)
[form ]

A crystalline solid
[color ]

White to off-white
Safety DataBack Directory
[Symbol(GHS) ]


GHS07
[Signal word ]

Warning
[Hazard statements ]

H302-H315-H319-H335
[Precautionary statements ]

P261-P305+P351+P338
[HS Code ]

2934999090
Hazard InformationBack Directory
[Biological Activity]

GLX351322 is an inhibitor of NADPH oxidase 4 (NOX4). It can inhibits tetracycline-induced hydrogen peroxide production in NOX4-overexpressing cells with IC50 of 5 μM.
[in vitro]

GLX351322 is an inhibitor of NADPH oxidase 4, and inhibits hydrogen peroxide production from NOX4-overexpressing cells with an IC 50 of 5 μM. GLX351322 shows weak activity against NOX2 in hPBMC cells ( IC 50 , 40 μM).

[in vivo]

GLX351322 (3.8 mg/kg/day, po) ameliorates HFD-induced hyperglycemia in mice.

[target]

TargetValue
NOX4
(Cell-free assay)
5 μM
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