| Identification | Back Directory | [Name]
5-(1,1-DIMETHYLHEPTYL)-2-[5-HYDROXY-2-(3-HYDROXYPROPYL)CYCLOHEXYL]PHENOL | [CAS]
83002-04-4 | [Synonyms]
CP 55667
CP55,667
CP-55667
CP 55,940
CP-55940 (CP 55,940)
(-)-Cis-3-[2-Hydroxy-4-(1,1-Di
(-)-CP 55940 (10 mg/mL in methanol)
(-)-CP 55,940 (10 mg/mL in methanol)
(-)-cis-3-[2-Hydroxy-4-(1,1-diMethy
lheptyl)ph
2-[5-hydroxy-2-(3-hydroxypropyl)cyclohexyl]-5-(2-Methyloctan-2-yl)phenol
5-(1,1-DIMETHYLHEPTYL)-2-[5-HYDROXY-2-(3-HYDROXYPROPYL)CYCLOHEXYL]PHENOL
3β-[4-(1,1-Dimethylheptyl)-2-hydroxyphenyl]-4α-(3-hydroxypropyl)cyclohexan-1β-ol
5-(1,1-DIMETHYLHEPTYL)-2-[(1R,2R,5R)-5-HYDROXY-2-(3-HYDROXYPROPYL)CYCLOHEXYL]PHENOL
Phenol,5-(1,1-diMethylheptyl)-2-[(1R,2R,5R)-5-hydroxy-2-(3-hydroxypropyl)cyclohexyl]-
(1R)-3β-[2-Hydroxy-4-(1,1-dimethylheptyl)phenyl]-4α-(3-hydroxypropyl)cyclohexane-1β-ol
(-)-CIS-3-[2-HYDROXY-4-(1,1-DIMETHYLHEPTYL)PHENYL]-TRANS-4-(3-HYDROXYPROPYL)CYCLOHEXANOL
(1α,2β,5α)-(-)-5-(1,1-DiMethylheptyl)-2-[5-hydroxy-2-(3-hydroxypropyl)
cyclohexyl]phenol
(-)-CIS-3-[2-HYDROXY-4-(1,1-DIMETHYLHEPTYL)PHENYL]-TRANS-4-(3-HYDROXYPHENYL) CYCLOHEXANOL | [Molecular Formula]
C24H40O3 | [MDL Number]
MFCD00673965 | [MOL File]
83002-04-4.mol | [Molecular Weight]
376.57 |
| Chemical Properties | Back Directory | [Melting point ]
65-68 °C | [Boiling point ]
494.4±45.0 °C(Predicted) | [density ]
1.026±0.06 g/cm3(Predicted) | [storage temp. ]
2-8°C | [solubility ]
DMSO: 15 mg/mL, soluble | [form ]
solid | [pka]
10.25±0.40(Predicted) | [optical activity]
[α]/D -24 to -30°, c =0.2 in chloroform-d |
| Hazard Information | Back Directory | [Uses]
(+)-CP 55940 is the enantiomer of (C781415), a cannabinoid agonist. Both CP 55,940 and (+)-CP 55940 bind to CB receptors but only CP-55,940 elicits a biological response via the receptors. However, (
+)-CP 55940 shows the same antinociceptive effects as its enantiomer. | [Uses]
CP 55,940 is a cannabinoid agonist which is considerably more potent than Δ9-THC in both behavioral tests and receptor binding assays. Displays high and roughly equal affinity for both central and peripheral cannabinoid receptors (Ki = 0.6 - 5.0 and 0.7 - 2.6 nM at CB1 and CB2 respectively; EC50 values are 0.2, 0.3 and 5 nM at CB1, CB2 and GRP55 respectively).
Controlled substance. | [Uses]
CP-55940 has been used as a cannabinoid agonists in Chinese hamster ovary (CHO) expressing cannabinoid receptor 2(CB2). | [Definition]
ChEBI: 2-[5-hydroxy-2-(3-hydroxypropyl)cyclohexyl]-5-(2-methyloctan-2-yl)phenol is an alkylbenzene and a ring assembly. | [Biological Activity]
Cannabinoid agonist which is considerably more potent than Δ 9 -THC in both behavioral tests and receptor binding assays. Displays high and roughly equal affinity for both central and peripheral cannabinoid receptors (K i = 0.6-5.0 and 0.7-2.6 nM at CB 1 and CB 2 respectively; EC 50 values are 0.2, 0.3 and 5 nM at CB 1 , CB 2 and GRP55 respectively). Also available as part of the Cannabinoid Receptor Agonist Tocriset™ . | [Biochem/physiol Actions]
CP-55940 is a nonclassical cannabinoids (NCCs), which lack the tetrahydropyran ring. CP-55940, a derivative of CP-47,497 is enantioselective. Due to its amphipathic nature, CP-55940 tethers in biological membrane making it favourable for the cannabinoid receptor interaction. CP-55940 belongs to the cyclohexylphenol category and modulates the brain lipidome leading to dysregulation especially during adolescence. It inhibits capsaicin-evoked sensitization of nociceptive and spinal dorsal horn neurons. | [storage]
Store at -20°C |
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