| Identification | Back Directory | [Name]
PSEUDOLARIC ACID B | [CAS]
82508-31-4 | [Synonyms]
PLAB
Pseudolaric acid
PSEUDOLARIC ACID B
Pseudolarix acid B
(-)-Pseudolaric Acid B
Pseudolaric Acid B(PBA)
Pseudolaric Acid B
(PAB)
pha(1e,3e),4-alpha,4a-alpha,9a-alpha)-(-)-(9ci)
Pseudolaric acid B, 98%, from Pseudolarix amabilis (J. Nelson) Rehder
-1,3-pentadienyl)3,4,4a,5,6,9-hexahydro-3-methyl-1-oxo-,7-methylester,(3-al
1h-4,9a-ethanocyclohepta(c)pyran-7-carboxylicacid,4a-(acetyloxy)-3-(4-carboxy
(2E,4E)-5-((3R,4S,4aS,9aS)-4a-acetoxy-7-(methoxycarbonyl)-3-methyl-1-oxo-3,4,4a,5,6,9-hexahydro-1H-4,9a-ethanocyclohepta[c]pyran-3-yl)-2-methylpenta-2,4-dienoic acid
1H-4,9a-Ethanocyclohepta[c]pyran-7-carboxylicacid,4a-(acetyloxy)-3-[(1E,3E)-4-carboxy-1,3-pentadien-1-yl]-3,4,4a,5,6,9-hexahydro-3-methyl-1-oxo-,7-methyl ester, (3R,4S,4aS,9aR)- | [EINECS(EC#)]
231-291-4 | [Molecular Formula]
C23H28O8 | [MDL Number]
MFCD01746346 | [MOL File]
82508-31-4.mol | [Molecular Weight]
432.46 |
| Chemical Properties | Back Directory | [Melting point ]
166°C | [Boiling point ]
466.14°C (rough estimate) | [density ]
1.2108 (rough estimate) | [refractive index ]
1.4480 (estimate) | [storage temp. ]
2-8°C | [solubility ]
methanol: soluble1mg/mL, clear, colorless | [form ]
powder or crystals | [pka]
4.52±0.19(Predicted) | [color ]
white to off-white | [InChIKey]
VDGOFNMYZYBUDT-YCONPBHISA-N |
| Hazard Information | Back Directory | [Description]
Pseudolaric acid B (PAB) is a diterpene acid isolated from the bark of P. kaempferi, a traditional Chinese medicinal plant. It has reported antifungal activities, consistent with its traditional use in the treatment of dermatological fungal infections.1 Moreover, PAB has diverse effects that are relevant to cancer therapy, including inducing apoptosis of cancer cells (IC50 = ~1 μM), preventing angiogenesis, and inhibiting tumor growth in vivo.2,3,4 | [Uses]
Activates PPARα and the phospholipase C (PLC) signalling pathway. Stimulates peroxisomal fatty acyl-CoA oxidase activity. These effects can be blocked by staurosporine . Exhibits significant cytotoxic activities against numerous tumor cell lines. Binds tubulin. Inhibits angiogenesis. Reduces HIF-1α protein levels. Induces apoptosis. Antifungal. | [Definition]
ChEBI: Pseudolaric acid B is a diterpene lactone. |
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