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ChemicalBook--->CAS DataBase List--->81627-83-0

81627-83-0

81627-83-0 Structure

81627-83-0 Structure
IdentificationBack Directory
[Name]

HUMAN M-CSF
[CAS]

81627-83-0
[Synonyms]

csf-1
M-CSF
MGI-IM
mCSF-1
mM-CSF
RHM-CSF
MGC31930
M-CSF rat
Lanimostim
HUMAN M-CSF
HUMAN CSF-1
HUMAN MGI-IM
M-CSF, HUMAN
M-CSF from rat
M-CSF from mouse
NATURAL HUMAN CSF-1
NATURAL HUMAN M-CSF
RECOMBINANT HUMAN M-CSF
colony-stimulatingfactor1
monocytecolony-stimulatingfactor
MACROPHAGE COLONY STIMULATING FACTOR
Recombinant Human M-CSF, HUMAN M-CSF
Macrophage colony-stimulating factor 1
HUMAN MACROPHAGE COLONY STIMULATING FACTOR
Recombinant Rat M-Csf/Csf1 Protein, No Tag
MACROPHAGE COLONY STIMULATING FACTOR, HUMAN
Recombinant Mouse M-Csf/Csf1 Protein, No Tag
cytokines,macrophagecolony-stimulatingfactor
Recombinant Human M-CSF/CSF1 Protein, His Tag
macrophagehumanrecombinantexpressedinyeast95+%
macrophage colony-stimulating factor from mouse
ANTI-M-CSF (CENTER) antibody produced in rabbit
Monoclonal Anti-CSF1 antibody produced in mouse
Processed macrophage colony-stimulating factor 1
MACROPHAGE COLONY STIMULATOR FACTOR (M-CSF) HUMAN
NATURAL HUMAN MACROPHAGE-COLONY STIMULATING FACTOR
Macrophage Colony-StimulatingFactor, Human, Recomb.
FOR USE IN THE MANUFACTURE OF MEDICAMENTS OF HS NO. 3002
MACROPHAGE COLONY-STIMULATING FACTOR, HUMAN, RECOMBINANT
Macrophage Colony-Stimulating Factor, Human, Recombinant, E. coli
MACROPHAGE-COLONY STIMULATING FACTOR, HU MAN RECOMBINANT EXPRESSED IN E. COLI
[MDL Number]

MFCD00241918
Chemical PropertiesBack Directory
[storage temp. ]

-20°C
[form ]

lyophilized powder
[color ]

white to off-white
[biological source]

rat
Safety DataBack Directory
[Symbol(GHS) ]


GHS07
[Signal word ]

Warning
[Hazard statements ]

H315-H319-H335
[Precautionary statements ]

P261-P264-P271-P280-P302+P352-P305+P351+P338
[Hazard Codes ]

Xi
[Risk Statements ]

36/37/38
[Safety Statements ]

22-24/25-26
[WGK Germany ]

3
[RTECS ]

GI5500000
Hazard InformationBack Directory
[Uses]

Macrophage Colony-Stimulating Factor from mouse has been used:
  • in the initiation of osteoclastogenesis in bone marrow monocyte cells
  • to stimulate osteoclast differentiation in non-adherent hematopoietic cell
  • for the generation of blood-derived stem cells

[Uses]

Antineoplastic; anti-infective growth factor that acts on both progenitor and mature cells of the macrophage line.
[General Description]

M-CSF (macrophage colony-stimulating factor) is a potent hematopoietic factor produced by a variety of cells including lymphocytes, monocytes, fibroblasts, endothelial cells, myoblasts and osteoblasts. The protein works through its receptor CSF1R (colony stimulating factor 1 receptor). The human is reactive in murine systems, but the murine molecule exhibits no activity on human cells. Recombinant murine M-CSF is a 36.4kDa homodimeric protein containing two 156 amino acid polypeptide subunits.
[Biochem/physiol Actions]

M-CSF (macrophage colony-stimulating factor) is a key regulator of cellular proliferation, differentiation, and survival of blood monocytes, tissue macrophages and their progenitor cells. M-CSF has been shown to play important roles in modulating dermal thickness, and male and female fertility. M-CSF is clinically used in the treatment of infection, malignancies and atherosclerosis. It facilitates hematopoietic recovery after bone marrow transplantation. M-CSF also works as a pleiotropic growth factor and plays a crucial role in reproduction and organogenesis. Absence of it can result in reduced growth, neurological and reproductive problems, developmental defects in the mammary gland, bone and pancreas. M-CSF is also involved in the pathogenesis of cancer.
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