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ChemicalBook--->CAS DataBase List--->81486-22-8

81486-22-8

81486-22-8 Structure

81486-22-8 Structure
IdentificationBack Directory
[Name]

NIPRADILOL
[CAS]

81486-22-8
[Synonyms]

K 351
KT 210
Hypadil
Nipranol
Nipradolol
NIPRADILOL
Ccris 2515
Brn 3566879
Nipradolol (10mM in DMSO)
NIPRANOL;NIPRADOLOL;NIPRADILOL;BRN 3566879
8-(2-Hydroxy-3-(isopropylamino)propoxy)-3-chromanyl nitrat
8-(2-Hydroxy-3-(isopropylaMino)propoxy)chroMan-3-yl nitrate
8-(2-Hydroxy-3-(isopropylamino)propoxy)-3-chromanol 3-nitrate
8-(2-Hydroxy-3-(isopropylamino)propoxy)-3-chromanol, 3-nitrate
3,4-Dihydro-8-(2-hydroxy-3-isopropylamino)propoxy-3-nitroxy-2H-1-benzopyran
3,4-Dihydro-8-(2-hydroxy-3-(isopropylamino)propoxy)-2H-1-benzopyran-3-ol 3-nitrate
3,4-Dihydro-8-[2-hydroxy-3-[(1-methylethyl)amino]propoxy]-2H-1-benzopyran-3-ol 3-nitrate
2H-1-Benzopyran-3-ol, 3,4-dihydro-8-(2-hydroxy-3-((1-methylethyl)amino)propoxy)-, 3-nitrate
[Molecular Formula]

C15H22N2O6
[MDL Number]

MFCD00864678
[MOL File]

81486-22-8.mol
[Molecular Weight]

326.34
Chemical PropertiesBack Directory
[Melting point ]

110-122℃
[Boiling point ]

464.39°C (rough estimate)
[density ]

1.1829 (rough estimate)
[refractive index ]

1.6280 (estimate)
Hazard InformationBack Directory
[Description]

Nipradilol is a beta-blocker with vasodilatory activity. As an antihypertensive nipradilol decreases systemic/pulmonary arterial blood pressure, heart rate, cardiac output and left ventricular volume without causing tachycardia. Nipradilol is also reported to have antiangina activity in dogs.
[Originator]

Kowa (Japan)
[Uses]

Nipradolol is a β-adrenoceptor blocking agent with antihypertensive properties.?Nipradolol is used as an?anti-glaucomatous agent.
[Definition]

ChEBI: Hypadil (TN) is an organic molecular entity.
[Brand name]

Hypadil
Safety DataBack Directory
[Toxicity]

LD50 i.v. in mice, rats: 74.0, 73.0 mg/kg; orally in mice: 540 mg/kg (Shiratsuchi, 1988)
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