| Identification | Back Directory | [Name]
Cd135 | [CAS]
81271-94-5 | [Synonyms]
flk2
Flt3
Mfr3
Sam3
Flt-3
Cd135
Flt3 active human
fl cytokine receptor
Cadmium, mass of 135
fms-related tyrosine kinase 3
FLT3 (571-993), active, GST tagged human
Recombinant Human FLRT3 Protein, His Tag
Recombinant Human CD135/FLT3 Protein, His Tag
Recombinant Mouse Flt-3 Ligand/Flt3 Protein, Fc Tag
Recombinant Mouse Flt-3 Ligand/Flt3 Protein, His Tag
ANTI-MOUSE FGFR3 (CENTER) antibody produced in rabbit | [Molecular Formula]
Cd | [MOL File]
81271-94-5.mol | [Molecular Weight]
112.411 |
| Hazard Information | Back Directory | [Uses]
Useful for the study of enzyme kinetics, screening inhibitors, and selectivity profiling. | [Definition]
ChEBI: Cadmium atom is a zinc group element atom. | [General Description]
Aquanal? kits can be used for the determination of hardness and phosphate ammonia, nitrate, and nitrite concentrations. | [Biological Activity]
FLT3 (fms-related tyrosine kinase 3)upon interaction with its ligandundergoes conformational changes to form homodimers. This results in phosphorylation and activation of downstream signaling pathways including phosphatidylinositol 3-kinase (PI3K/AKT)mitogen-activated protein kinase/extracellular signal-regulated kinase (MAPK/ERK) and signal transducer and activator of transcription 5 (STAT5) pathways. Internal tandem duplication (ITD) mutation or a point mutation in juxtamembrane domain-coding region or within the activation loop domainrespectivelyof this gene lead to its constitutive action. FLT3/ITD mutation is associated with later stages of acute myeloid leukemia (AML) pathogenesis. These patients have poor prognosis. |
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