| Identification | Back Directory | [Name]
PARAFFIN | [CAS]
8012-95-1 | [Synonyms]
OIL
NUJOL
molol
saxol
glymol
kaydol
balneol
bayol55
drakeol
primold
penreco
BAYOL F
ultrol7
techpetf
thermiac
PARAFFIN
alboline
protopet
peneteck
fonoline
crystosol
flexon845
blandlube
kondremul
paraffins
paroleine
primol355
sunpar150
whiteoils
neo-cultol
irgawax361
petrogalar
magiesol44
crystol325
adepsineoil
TAN STANDARD
OIL, MINERAL
Paraffinoils
Paraffin oil
uspmineraloil
shellflex371n
petrolatum,liq
liquidvaseline
huiledepetrole
MINERALOILMIST
heavymineraloil
oilmist,mineral
PARAFFIN LIQUID
LIQUID PARAFFIN
LIGHT WHITE OIL
OIL BATH FILLING
oilmist(mineral)
C1-C6 N-PARAFFINS
LIQUID PETROLATUM
PETROLATUM LIQUID
WASTE MINERAL OIL
Nujol (light oil)
PARAFFINICWHITEOIL
LIGHTMINERALOIL,NF
MINERAL OIL MEDIUM
MINERAL OIL, HEAVY
MINERAL OIL, LIGHT
MINERAL OIL, WHITE
PARAFFIN OIL LIGHT
PARAFFIN OIL, HEAVY
(componentof)agoral
Mineral Oil (1.5 mL)
petroleumhydrocarbons
heavyliquidpetrolatum
(componentof)alphakeri
LOWVISCOSITYMINERALOIL
Mineraloil~Paraffinoil
Paraffin, liquid, pure
Light Mineral Oil Blank
(componentof)kerilotion
MINERAL OIL EXTRA HEAVY
PARAFFIN OIL, LIGHT NO 5
MINERAL OIL, LIGHT, NO 5
MINERAL OIL, HEAVY, NO 21
MINERAL OIL, WHITE, HEAVY
MINERAL OIL, WHITE, LIGHT
Oil mist, refined mineral
MINERALOIL(HIGHVISCOSITY)
Paraffin, liquid, pure 1LT
MINERALOIL,LIGHT,TECH(BULK
MINERALOIL,WHITE,HEAVY,FCC
MINERALOIL,WHITE,LIGHT,FCC
Total Acid Number Standard
Nujol, for IR spectroscopy
MINERALOIL,WHITE,MEDIUM,FCC
Paraffin, liquid, technical
MINERALOIL,70DUOPRIMEUSP(BULK
ParafinLiquidColourless,Heavy
ParafinLiquidColourless,Light
PARAFFIN OIL PRG(CRM STANDARD)
ParaffinLiquidForIrSpectroscopy
Mineraloil(saturatedparrafinoil)
PARAFFIN OIL, FOR IR-SPECTROSCOPY
1 4-DIOXAN SPECTRANAL STABILIZED
MINERALOIL(MEDIUMANDLOWVISCOSITY)
MINERALOIL,HEAVYVISCOSITYRANGE,USP
VASELINE OIL COLOURLESS FOOD GRADE
VASELINE OIL EXTRA PURE COSMETIC GRADE
Mineraloilhydrocarbonsolvent(petroleum)
LIGHT WHITE MINERAL OIL, SULFURDEPLETED
MINERAL OIL, WITHOUT ADDITIVES, DIN H 53
MINERAL OIL STANDARD MIXTURE TYPE A AND B
MINERAL OIL, WITHOUT ADDITIVES, DIN H53 EN9377-2
PARAFFIN VISCID, EXTRA PURE, DAB, PH. EU R., B. P., PH. FRANC. | [EINECS(EC#)]
232-455-8 | [Molecular Formula]
CnH2n+2 n=16~24 | [MDL Number]
MFCD00131611 |
| Chemical Properties | Back Directory | [Appearance]
Clear colorless oil | [Melting point ]
-24 °C (lit.) | [Boiling point ]
300 °C (lit.) | [density ]
0.85 g/mL at 20 °C
| [refractive index ]
n20/D 1.467(lit.)
| [Fp ]
>300°C | [storage temp. ]
Store at room temperature. | [solubility ]
Practically insoluble in ethanol (95%), glycerin, and
water; soluble in acetone, benzene, chloroform, carbon disulfide,
ether, and petroleum ether. Miscible with volatile oils and fixed
oils, with the exception of castor oil. | [form ]
light oil
| [color ]
white
| [Specific Gravity]
0.870 (20/4℃) | [Odor]
Odorless | [Water Solubility ]
Soluble in ether. Sparingly soluble in ethanol. Not miscible or difficult to mix in water. | [Merck ]
14,7023 | [Dielectric constant]
2.0（Ambient） | [Exposure limits]
ACGIH: TWA 5 mg/m3
OSHA: TWA 5 mg/m3
NIOSH: IDLH 2500 mg/m3; TWA 5 mg/m3; STEL 10 mg/m3 | [EPA Substance Registry System]
Paraffin oils(8012-95-1) |
| Hazard Information | Back Directory | [Chemical Properties]
Clear colorless oil | [General Description]
Transparent colorless oily liquid. Practically tasteless and odorless, even when warmed. | [Air & Water Reactions]
Flammable. Insoluble in water. | [Reactivity Profile]
OIL. [MINERAL] may be incompatible with strong oxidizing agents like nitric acid. Charring may occur followed by ignition of unreacted oil and other nearby combustibles. In other settings, mostly unreactive. Not affected by aqueous solutions of acids, alkalis, most oxidizing agents, and most reducing agents. Burns exothermically when heated sufficiently or when ignited in the presence of air, oxygen or strong oxidizing agents. | [Fire Hazard]
PARAFFIN is combustible. | [Hazard]
Inhalation of vapor or particulates can causeaspiration pneumonia. Combustible liquid. Upperrespiratory tract irritant. Questionable carcinogen. | [Description]
Mineral oil mist is a colorless, oily liquid aero-sol dispersed in air with an odor like burned lubricating oil.The odor threshold is 1.0 ppm. Specific gravity (H2O:1)=0.865 at 60℃; Boiling point = 250- 360*C; Vaporpressure = <0.5 mmHg at 20℃; Flash point= 193℃;Autoignition temperature = 260- 371℃. HazardIdentification (based on NFPA-704 M Rating System):Health 0, Flammability 1, Reactivity 0. Insoluble in water. | [Uses]
Laxative; pharmaceutic aid (solvent). | [Uses]
Mineral oil is a lubricant and is used as
a solvent for inks in the printing industry. | [Uses]
Paraffin Oils is a useful organic solvent for isolating the nucleus of the gian amphibian oocyte. | [Definition]
Liquid hydrocarbons from petroleum. | [Production Methods]
Mineral oil is obtained by distillation of petroleum. The lighter
hydrocarbons are first removed by distillation and the residue is
then redistilled between 330–390°C. The distillate is chilled and the
solid fractions are removed by filtration. The filtrate is then further
purified and decolorized by high-pressure hydrogenation or sulfuric
acid treatment; the purified filtrate is then filtered through
adsorbents. The liquid portion obtained is distilled and the portion
boiling below 360°C is discarded. A suitable stabilizer may be
added to the mineral oil; | [Brand name]
Balneol
(Solvay Pharmaceuticals); Neo-Cultol (Fisons); Nujol
(Schering-Plough HealthCare). | [Health Hazard]
Highly refined mineral oil mist
is of low toxicity. | [Pharmaceutical Applications]
Mineral oil is used primarily as an excipient in topical pharmaceutical
formulations, where its emollient properties are exploited as an
ingredient in ointment bases. It is additionally used in
oil-in-water emulsions,as a solvent, and as a lubricant in
capsule and tablet formulations, and to a limited extent as a mold-release agent for cocoa butter suppositories. It has also been used in
the preparation of microspheres and as a vaccine adjunct.
Therapeutically, mineral oil has been used as a laxative.It is indigestible and thus has limited absorption.
Mineral oil is used in ophthalmic formulations for its lubricant
properties. It is also used in cosmetics and some food products. | [Safety]
Mineral oil is used as an excipient in a wide variety of
pharmaceutical formulations. It is also used in
cosmetics and in some food products.
Therapeutically, mineral oil has been used in the treatment of
constipation, as it acts as a lubricant and stool softener when taken
orally. Daily doses of up to 45mL have been administered orally,
while doses of up to 120mL have been used as an enema. However,
excessive dosage of mineral oil, either orally or rectally, can result in
anal seepage and irritation, and its oral use as a laxative is not
considered desirable.
Chronic oral consumption of mineral oil may impair the appetite
and interfere with the absorption of fat-soluble vitamins. Prolonged
use should be avoided. Mineral oil is absorbed to some extent when
emulsified and can lead to granulomatous reactions. Similar
reactions also occur upon injection of the oil;injection may
also cause vasospasm.
The most serious adverse reaction to mineral oil is lipoid
pneumonia caused by aspiration of the oil.Mineral oil can
enter the bronchial tree without eliciting the cough reflex.With
the reduction in the use of mineral oil in nasal formulations, the
incidence of lipoid pneumonia has been greatly reduced. However,
lipoid pneumonia has also been associated with the use of mineral
oil-containing cosmetics and ophthalmic preparations.It is
recommended that products containing mineral oil not be used in
very young children, the elderly, or persons with debilitating
illnesses.
Given its widespread use in many topical products, mineral oil
has been associated with few instances of allergic reactions.
The WHO has not specified an acceptable daily intake of
mineral oil given the low concentration consumed in foods.
LD50 (mouse, oral): 22 g/kg | [Potential Exposure]
Tumorigen,Human Data; Primary Irritant. Mineral oil is used in cosmetics, pharmaceutical bases, food, and fiber production; ascarriers and bases; as a lubricating oil; and as a solvent forinks in the printing industry. Oil mist would be encounteredin quenching of hot metal parts and in metal machiningoperations. | [First aid]
If this chemical gets into the eyes, remove anycontact lenses at once and irrigate immediately for at least15 min, occasionally lifting upper and lower lids. Seek medical attention immediately. If this chemical contacts theskin, remove contaminated clothing and wash immediatelywith soap and water. Seek medical attention immediately. Ifthis chemical has been inhaled, remove from exposure,begin rescue breathing (using universal precautions, including resuscitation mask) if breathing has stopped and CPR ifheart action has stopped. Transfer promptly to a medicalfacility | [storage]
Mineral oil undergoes oxidation when exposed to heat and light.
Oxidation begins with the formation of peroxides, exhibiting an
‘induction period’. Under ordinary conditions, the induction period
may take months or years. However, once a trace of peroxide is
formed, further oxidation is autocatalytic and proceeds very
rapidly. Oxidation results in the formation of aldehydes and
organic acids, which impart taste and odor. Stabilizers may be added to retard oxidation; butylated hydroxyanisole, butylated
hydroxytoluene, and alpha tocopherol are the most commonly used
antioxidants.
Mineral oil may be sterilized by dry heat.
Mineral oil should be stored in an airtight container, protected
from light, in a cool, dry place. | [Purification Methods]
Treat the oil with fuming H2SO4 (care), then wash it with water and dilute aqueous NaOH, then percolate it through activated silica gel. Paraffin Wax. Melt the wax in the presence of NaOH, wash it with water until all of the base had been removed. The paraffin is allowed to solidify after each wash. Finally, 5g of paraffin is melted by heating it on a water-bath, then shaken for 20-30minutes with 100mL of boiling water and and dry the melt under vacuum. | [Incompatibilities]
Incompatible with strong oxidizing agents. | [Regulatory Status]
GRAS listed. Accepted in the UK for use in certain food
applications. Included in the FDA Inactive Ingredients Database
(dental preparations; IV injections; ophthalmic preparations; oral
capsules and tablets; otic, topical, transdermal, and vaginal
preparations). Included in nonparenteral medicines licensed in the UK. Included in the Canadian List of Acceptable Non-medicinal
Ingredients. |
| Safety Data | Back Directory | [Hazard Codes ]
Xi,N | [Risk Statements ]
36-51/53 | [Safety Statements ]
26-61 | [WGK Germany ]
1
| [RTECS ]
PY8030000 | [Autoignition Temperature]
245°C | [TSCA ]
Yes | [HS Code ]
27122090 | [Safety Profile]
A human teratogen by
inhalation that causes testicular tumors in
the fetus. Inhalation of vapor or particulates
can cause aspiration pneumonia. A skin and
eye irritant. Highly purified food grades are
of low toxicity. Questionable human
carcinogen producing gastrointestinal
tumors. Slightly combustible liquid when
exposed to heat or flame. To fight fire, use
dry chemical, CO2, foam. When heated to
decomposition it emits acrid smoke and
fumes. | [Hazardous Substances Data]
8012-95-1(Hazardous Substances Data) | [Toxicity]
LD50 oral in rat: > 24gm/kg | [IDLA]
2,500 mg/m3 |
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