| Identification | Back Directory | [Name]
(S)-phosphoric acid Mono-[3-(4-benzyloxy-phenyl)-2-octadec-9-enoylaMino-propyl] ester (aMMoniuM salt) | [CAS]
799268-73-8 | [Synonyms]
VPC 12249 (S)
(S)-phosphoric acid Mono-[3-(4-benzyloxy-phenyl)-2-octadec-9-enoylaMino-propyl] ester (aMMoniuM salt)
(S)-PHOSPHORIC ACID MONO-[3-(4-BENZYLOXY-PHENYL)-2-OCTADEC-9-ENOYLAMINO-PROPYL] ESTER (AMMONIUM SALT);VPC 12249 (S) | [Molecular Formula]
C34H55N2O6P | [MDL Number]
MFCD22416852 | [MOL File]
799268-73-8.mol | [Molecular Weight]
618.8 |
| Hazard Information | Back Directory | [Uses]
VPC 12249 has been used as lysophosphatidic acid (LPA)1/3 receptor antagonist in various experimental studies. | [General Description]
VPC 12249 is an N-acyl (oleoyl) serine phosphate-based compound. | [Biochem/physiol Actions]
Lysophosphatidic acids (LPAs) are bioactive lipid mediators. It interacts with at least six specific LPA receptors (LPA1-6) to mediate extracellular signaling pathway. LPA and its receptors (LPA1-3) are implicated in the pathogenesis of radiation pneumonitis (RP). VPC 12249 (S) inhibits the binding ofLPA to LPA1 and LPA3 receptor. |
|
| Company Name: |
Sigma-Aldrich
|
| Tel: |
021-61415566 800-8193336 |
| Website: |
https://www.sigmaaldrich.cn |
| Company Name: |
Merck KGaA
|
| Tel: |
(+86) 21 2033 8288 |
| Website: |
http://www.sigmaaldrich.cn |
| Company Name: |
Creative Enzymes
|
| Tel: |
1-516-855-7709 |
| Website: |
www.creative-enzymes.com |
|