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ChemicalBook--->CAS DataBase List--->793719-01-4

793719-01-4

793719-01-4 Structure

793719-01-4 Structure
IdentificationBack Directory
[Name]

N-[2-Chloro-5-[(dimethylamino)sulfonyl]phenyl]-2-propenamide
[CAS]

793719-01-4
[Synonyms]

EN450
N-[2-Chloro-5-[(dimethylamino)sulfonyl]phenyl]-2-propenamide
[Molecular Formula]

C11H13ClN2O3S
[MOL File]

793719-01-4.mol
[Molecular Weight]

288.75
Chemical PropertiesBack Directory
[density ]

1.364±0.06 g/cm3(Temp: 20 °C; Press: 760 Torr)(Predicted)
[storage temp. ]

2-8°C
[solubility ]

DMSO: 2mg/mL, clear
[form ]

Solid
[pka]

12.16±0.70(Predicted)
[color ]

White to off-white
Hazard InformationBack Directory
[Biological Activity]

EN450 is a molecular glue degraders of the oncogenic transcription factor NFKB1 th at induces ternary complex formation between ubiquitin-conjugating enzyme E2D1 (UBE2D1) and NFKB1. EN450 covalently modifies an allosteric C111 in UBE2D1 and significantly reduces NFKB1 p105 levels. It impairs leukemia cell viability in a NEDDylation and proteasome-dependent manner at 50 μM.
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