| Identification | Back Directory | [Name]
1-O-HEXADECYL-2-O-ETHYL-SN-GLYCERO-3-PHOSPHORYLCHOLINE | [CAS]
78858-42-1 | [Synonyms]
E-PAF
2-O-ETHYL-PAF
2-O-ETHYL PAF C-16
LPHUUVMLQFHHQG-AREMUKBSSA-N
1-O-HEXADECYL-2-O-ETHYL-SN-GLYCERO-3-PHOSPHORYLCHOLINE
1-O-HEXADECYL-2-O-ETHYL-SN-GLYCERYL-3-PHOSPHORYLCHOLINE | [Molecular Formula]
C26H56NO6P | [MDL Number]
MFCD00210997 | [MOL File]
78858-42-1.mol | [Molecular Weight]
509.7 |
| Hazard Information | Back Directory | [Description]
2-O-ethyl PAF C-16 is a synthetic PAF analog which contains an ethyl group, attached by an ether linkage, at the sn-2 position. It is a less potent agonist than methylcarbamyl PAF C-16 in the induction of platelet aggregation in both human and rabbit PRP. 2-O-ethyl PAF C-16 causes aggregation of neutrophils in the presence of divalent cations and a desensitization to aggregation in the absence of divalent cations. | [Uses]
2-O-Ethyl PAF C-16 is a homolog of PAF and a competitive ligand for PAF receptor (Platelet-activating Factor Receptor (PAFR)). 2-O-Ethyl PAF C-16 inhibits the binding of the PAF antagonist WEB 2086 (HY-108634) to the PAF receptor with an IC50 of 21 nM[1]. | [Definition]
ChEBI: 2-O-ethyl PAF C-16 is a glycerophosphocholine and an ether lipid. | [References]
[1] Aoki Y, et al. A radioreceptor binding assay for platelet-activating factor (PAF) using membranes from CHO cells expressing human PAF receptor. J Immunol Methods. 1995 Oct 26;186(2):225-31. DOI:10.1016/0022-1759(95)00147-3 |
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