| Identification | Back Directory | [Name]
DerMorphin Trifluoroacetate | [CAS]
78331-26-7 | [Synonyms]
Dermorphin TFA
DerMorphin Trifluoroacetate
DerMorphin Trifluoroacetic Acid Salt | [Molecular Formula]
C40H50N8O10 | [MOL File]
78331-26-7.mol | [Molecular Weight]
802.873 |
| Hazard Information | Back Directory | [Chemical Properties]
White Solid | [Uses]
Dermorphin is a hepta-peptide and a natural opioid initially isolated from the skin of South American hylid frogs Phyllomedusinae. Dermorphin binds as an agonist with high potency and selectivity to mu-opioid receptors. Dermorphin is about 30-40 times more potent than Morphine. | [IC 50]
μ Opioid Receptor/MOR | [References]
[1] Tiwari V, et al. Activation of Peripheral μ-opioid Receptors by Dermorphin [D-Arg2, Lys4] (1-4) Amide Leads to Modality-preferred Inhibition of Neuropathic Pain. Anesthesiology. 2016 Mar;124(3):706-20. DOI:10.1097/ALN.0000000000000993
[2] Bird MF, et al. Characterisation of the Novel Mixed Mu-NOP Peptide Ligand Dermorphin-N/OFQ (DeNo). PLoS One. 2016 Jun 7;11(6):e0156897. DOI:10.1371/journal.pone.0156897 |
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