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ChemicalBook--->CAS DataBase List--->77518-23-1

77518-23-1

77518-23-1 Structure

77518-23-1 Structure
IdentificationBack Directory
[Name]

Norhyodeoxycholic Acid
[CAS]

77518-23-1
[Synonyms]

Norhyodeoxycholic Acid
[Molecular Formula]

C23H38O4
[MOL File]

77518-23-1.mol
[Molecular Weight]

378.55
Chemical PropertiesBack Directory
[storage temp. ]

Store at -20°C
[solubility ]

DMF: 30mg/mL; DMF:PBS (pH 7.2) (1:1): 0.5mg/mL; DMSO: 20mg/mL; Ethanol: 20mg/mL
[form ]

A crystalline solid
Hazard InformationBack Directory
[Description]

Norhyodeoxycholic acid (NHDCA) is a synthetic bile acid and a derivative of hyodeoxycholic acid (HDCA; ).1,2 NHDCA is an intermediate in the synthesis of 3β-sulfooxy-7β-hydroxy-24-nor-5-cholen-23-oic acid, which has been used as an internal standard for the quantification of Δ5-bile acid conjugates that have been identified in patients with Niemann-Pick disease type C1.3
[Definition]

ChEBI: Norhyodeoxycholic acid is a cholanoid.
[References]

1. Schteingart, C.D., and Hofmann, A.F. Synthesis of 24-nor-5β-cholan-23-oic acid derivatives: A convenient and efficient one-carbon degradation of the side chain of natural bile acids J. Lipid Res. 29(10),1387-1395(1988).
2. Une, M., and Hoshita, T. Natural occurrence and chemical synthesis of bile alcohols, higher bile acids, and short side chain bile acids Hiroshima J. Med. Sci. 43(2),37-67(1994).
3. Kakiyama, G., Muto, A., Shimada, M., et al. Chemical synthesis of 3β-sulfooxy-7β-hydroxy-24-nor-5-cholenoic acid: An internal standard for mass spectrometric analysis of the abnormal Δ5-bile acids occurring in Niemann-Pick disease Steroids 74(9),766-772(2009).
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