| Identification | Back Directory | [Name]
(9E,12Z)-10-Nitrooctadecadienoic acid | [CAS]
774603-04-2 | [Synonyms]
10-Nitrolinoleate
10-Nitrolinoleic acid
LELVHAQTWXTCLY-XYWKCAQWSA-N
10-Nitro-9Z,12Z-octadecadienoic acid
(9E,12Z)-10-Nitrooctadecadienoic acid
10-Nitro-9(E)-12(Z)-Octadecadienoic acid
10 Nitrolinoleic acid,10Nitrolinoleic acid
9,12-Octadecadienoic acid, 10-nitro-, (9E,12Z)- | [Molecular Formula]
C18H31NO4 | [MOL File]
774603-04-2.mol | [Molecular Weight]
325.44 |
| Chemical Properties | Back Directory | [Boiling point ]
452.2±33.0 °C(Predicted) | [density ]
1.016±0.06 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
DMF: 30 mg/ml; DMSO: 25 mg/ml; Ethanol: 30 mg/ml; Ethanol:PBS(pH 7.2) (1:1): 0.5 mg/ml | [form ]
Liquid | [pka]
4.77±0.10(Predicted) | [color ]
Colorless to light yellow |
| Hazard Information | Back Directory | [Description]
10-Nitrolinoleate is a nitrated fatty acid and a peroxisome proliferator-activated receptor γ (PPARγ) agonist. It is formed from linoleic acid (Item Nos. 90150 | 90150.1 | 21909) upon exposure to acidified nitrite. | [Uses]
10-Nitrolinoleic acid is a potent peroxisome proliferator-activated receptor γ (PPARγ) agonist. 10-Nitrolinoleic acid competes with [3H]Rosiglitazone for binding to PPAR-γ, with an IC50 of 0.22 μM[1]. | [Definition]
ChEBI: 10-Nitro-9Z,12Z-octadecadienoic acid is a nitro fatty acid and an octadecadienoic acid. | [IC 50]
PPARγ: 0.22 μM (IC50) | [References]
[1] Dunny E, et, al. Stereocontrolled synthesis of the PPAR-gamma agonist 10-nitrolinoleic acid. J Org Chem. 2010 Aug 6;75(15):5334-6. DOI:10.1021/jo1007493 |
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