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ChemicalBook--->CAS DataBase List--->774549-97-2

774549-97-2

774549-97-2 Structure

774549-97-2 Structure
IdentificationBack Directory
[Name]

KM 11060
[CAS]

774549-97-2
[Synonyms]

KM 11060
KM11060;KM-11060
CFTR-F508del Corrector, KM11060
7-CHLORO-4-(4-(4-CHLOROPHENYLSULFONYL)PIPERAZIN-1-YL)QUINOLINE
7-CHLORO-4-[4-[4-CHLOROPHENYL)SULFONYL]-1-PIPERAZINYL]QUINOLINE
Quinoline, 7-chloro-4-[4-[(4-chlorophenyl)sulfonyl]-1-piperazinyl]-
[Molecular Formula]

C19H17Cl2N3O2S
[MDL Number]

MFCD01524977
[MOL File]

774549-97-2.mol
[Molecular Weight]

422.33
Chemical PropertiesBack Directory
[storage temp. ]

Store at RT
[solubility ]

Soluble to 100 mM in DMSO and to 10 mM in ethanol
[form ]

Powder
[color ]

White to off-white
Safety DataBack Directory
[Symbol(GHS) ]


GHS07
[Signal word ]

Warning
[Hazard statements ]

H302-H315-H319-H335
[Precautionary statements ]

P261-P305+P351+P338
[Hazard Codes ]

T
[Risk Statements ]

25
[Safety Statements ]

45
Hazard InformationBack Directory
[Uses]

KM 11060 is a small molecular corrector of F508del CFTR trafficking, which has potential application in cystic fibrosis therapeutics.
[Biological Activity]

Corrects F508del-CFTR trafficking; increases the amount of functional CFTR at the plasma membrane (~75%). Shown to inhibit PDE5 activity.
[storage]

Store at RT
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