| Identification | Back Directory | [Name]
(-)-MK-801 MALEATE | [CAS]
77086-22-7 | [Synonyms]
mk801
(+)MK801
(+)MK108
MK 801 ;MK801
Dizocipine maleate
(-)-MK-801 MALEATE
(+)Mk801/MK801/MK-801
(+)-MK-801·Maleic acid
MK-801(Dizocilpine)Maleate
(+/-)-mk-801 hydrogen maleate
Dizocilpine hydrogen maleate
Dizocilpine Maleate [(+)-MK 801 maleate
(+)-MK 801 Maleate - CAS 77086-22-7 - Calbiochem
(+)-MK-801 HYDROGEN MALEATE (DIZOCILPINE MALEATE)
[5R,(-)]-10,11-Dihydro-5-methyl-5H-dibenzo[a,d]cyclohepten-5β,10β-imine
DIZOCILPINE MALEATE;DIZOCILPINE HYDROGEN MALEATE;(+)-MK 801;MK 801;MK801
[5R,10S,(-)]-10,11-Dihydro-5-methyl-5H-dibenzo[a,d]cyclohepten-5,10-imine
[5R,10S,(-)]-10,11-Dihydro-5-methyl-5H-dibenzo[a,d]cyclohepten-5β,10β-imine
(5S,10R)-5-Methyl-10,11-dihydro-5H-5,10-epiminodibenzo[a,d][7]annulene maleate
(+)-10,11-dihydro-5-methyl-5H-dibenzo[a,d]cyclohepten-5,10-diyldiammonium maleate
(+)-10,11-dihydro-5-methyl-5H-dibenzo[a,d]cyclohepten-5,10-diyldiammonium maleate
(5S,10R)-(-)-5-METHYL-10,11-DIHYDRO-5H-DIBENZO[A,D]CYCLOHEPTEN-5,10-IMINE MALEATE
d)cyclohepten-5,10-imine,10,11-dihydro-5-methyl-5h-dibenzo((5s)-5h-dibenzo((z)-2-b
5-Methyl-10,11-dihydro-5H-5,10-epiMinodibenzo[a,d][7]annulene (2Z)-but-2-enedioate
(5S,10R)-(+)-5-Methyl-10,11-dihydro-(5H)-dibenzo[a.d]cycloheptene-5,10-iminemaleate
(5S)-10,11-Dihydro-5-methyl-5H-dibenzo[a,d]cyclohepten-5,10-imine (Z)-2-butenedioate
Dizocilpine hydrogen maleate, (5R,10S)-(+)-5-Methyl-10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5,10-imine hydrogen maleate
inhibit,anticonvulsant,neurotransmitter,noncompetitive,ambulation,MK-801,Dizocilpine Maleate,voltage,hyperlocomotion,Ionotropic glutamate receptors,Inhibitor,iGluR,MK801,Dizocilpine | [EINECS(EC#)]
278-614-5 | [Molecular Formula]
C20H19NO4 | [MDL Number]
MFCD00082465 | [MOL File]
77086-22-7.mol | [Molecular Weight]
337.37 |
| Chemical Properties | Back Directory | [Melting point ]
208.5-210° | [alpha ]
D20 +114° (c = 0.0128 g/2 ml ethanol) | [storage temp. ]
Inert atmosphere,2-8°C | [solubility ]
DMSO: >20 mg/mL
| [form ]
solid
| [color ]
white
| [optical activity]
[α]25/D +117°, c = 1 in methanol(lit.) | [Water Solubility ]
water: 3mg/mL
ethanol: soluble | [InChIKey]
QLTXKCWMEZIHBJ-FWHYOZOBSA-N |
| Hazard Information | Back Directory | [Uses]
(-)-MK-801 MALEATE acts as an NMDA receptor antagonist. It is selective and potent, but noncompetitive, used in various ischemia treatments.
| [Uses]
(-)-MK-801 MALEATE is probe for NMDA receptors
| [Definition]
ChEBI: Dizocilpine maleate is a maleate salt obtained by reaction of dizocilpine with one equivalent of maleic acid. It has a role as an anaesthetic, an anticonvulsant, a neuroprotective agent, a nicotinic antagonist and a NMDA receptor antagonist. It is a maleate salt and a tetracyclic antidepressant. It contains a dizocilpine(1+). | [General Description]
A highly potent, selective and non-competitive NMDA receptor antagonist that acts by binding to a site located within the NMDA associated ion channel, preventing Ca2+ flux. An effective anti-ischemic agent in several animal models. Has been used to develop an in vivo model of NMDA receptor-dependent apoptotic neurodegenerative disease in developing rat brains. Has also been used to develop an in vitro model of NMDA receptor-specific Ca2+ entry induced seizures. | [Biological Activity]
(-)-MK-801 MALEATE is a potent, selective and non-competitive NMDA receptor antagonist. Acts by binding to a site located within the NMDA associated ion channel and thus prevents Ca 2+ flux. An effective anti-ischemic agent in several animal models. Also available as part of the Mixed NMDA Receptor Tocriset™ .
| [Biochem/physiol Actions]
Primary TargetNMDA receptor | [storage]
Store at -20°C | [References]
[1] wong eh, kemp ja, priestley t, knight ar, woodruff gn, iversen ll . the anticonvulsant mk-801 is a potent n-methyl-d-aspartate antagonist. proc natl acad sci u s a. 1986 sep;83(18):7104-8. |
|
|