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ChemicalBook--->CAS DataBase List--->757192-67-9

757192-67-9

757192-67-9 Structure

757192-67-9 Structure
IdentificationBack Directory
[Name]

Acetamide, 2-chloro-N-(2-cyanoethyl)-N-(2,3-dihydro-1,4-benzodioxin-6-yl)-
[CAS]

757192-67-9
[Synonyms]

EN106
Acetamide, 2-chloro-N-(2-cyanoethyl)-N-(2,3-dihydro-1,4-benzodioxin-6-yl)-
[Molecular Formula]

C13H13ClN2O3
[MOL File]

757192-67-9.mol
[Molecular Weight]

280.71
Chemical PropertiesBack Directory
[Boiling point ]

489.1±45.0 °C(Predicted)
[density ]

1.351±0.06 g/cm3(Predicted)
[storage temp. ]

Store at -20°C
[solubility ]

DMSO : 250 mg/mL (890.60 mM; Need ultrasonic)
[form ]

Solid
[pka]

0.42±0.20(Predicted)
[color ]

White to off-white
Hazard InformationBack Directory
[Biological Activity]

EN106 is a cell-permeable covalent recruiter of CUL2 E3 ligase FEM1B th at binds to C186 of FEM1B. EN106 disrupts FEM1B interactions with the FNIP1 degron and inhibits CUL2FEM1B-dependent ubiquitylation without detectable off-target effects. A modified EN106 bifunctional analog (PROTAC) recruits FEM1B and induces targeted BRD4 and BCR-ABL/c-ABL degradation.
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