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ChemicalBook--->CAS DataBase List--->756526-03-1

756526-03-1

756526-03-1 Structure

756526-03-1 Structure
IdentificationBack Directory
[Name]

Bis(NHS)PEG5
[CAS]

756526-03-1
[Synonyms]

756526-03-1
Bis(NHS)PEG5
BIS-PEG5-NHS
NHS-PEG5-NHS
PEG5 BIS-NHS ESTER
Bis-PEG5-NHS ester
Bis-PEG6-NHS ester
Bis-dPEG5-NHS ester
Bis-dPEG(R)5-NHS ester
Bis(3-PEG4)propionic acid N-hydroxysuccinimide diester
Di(N-succinimidyl) 4,7,10,13,16-Pentaoxanonadecanedioate
4,7,10,13,16-Pentaoxanonadecanedioic Acid Di(N-succinimidyl) Ester
Bis(2,5-dioxopyrrolidin-1-yl) 4,7,10,13,16-pentaoxanonadecane-1,19-dioate
4,7,10,13,16-Pentaoxanonadecanedioic acid, 1,19-bis(2,5-dioxo-1-pyrrolidinyl) ester
[Molecular Formula]

C22H32N2O13
[MDL Number]

MFCD11041118
[MOL File]

756526-03-1.mol
[Molecular Weight]

532.51
Chemical PropertiesBack Directory
[Boiling point ]

632.5±65.0 °C(Predicted)
[density ]

1.37±0.1 g/cm3(Predicted)
[storage temp. ]

<0°C
[solubility ]

Soluble in DMSO, DCM, DMF
[form ]

solid or viscous liquid
[color ]

Colorless to Almost colorless
[Water Solubility ]

water: soluble
[CAS DataBase Reference]

756526-03-1
Safety DataBack Directory
[HS Code ]

2928.00.5000
Hazard InformationBack Directory
[Description]

Bis-PEG5-NHS ester is a PEG linker containing two NHS ester groups. The hydrophilic PEG spacer increases solubility in aqueous media. The NHS ester can be used to label the primary amines (-NH2) of proteins, amine-modified oligonucleotides, and other amine-containing molecules.
[Uses]

Bis(NHS)PEG5 is used in targeting M2-like tumor-associated macrophages by using melittin-based pro-apoptotic peptide conjugates with anti-cancer drugs,
[General Description]

By contrast to typical PEG reagents that contain heterogeneous mixtures of different PEG chain lengths, this PEG reagent is a homogeneous compound of defined molecular weight and spacer arm length, providing greater precision in optimization and characterization of crosslinking applications. Homobifunctional crosslinkers containing N-hydroxysuccinimide (NHS) esters are often used for low-resolution 3-D studies of protein structure and protein interaction analysis.
[reaction suitability]

reagent type: cross-linking reagent
reactivity: amine reactive
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