| Identification | Back Directory | [Name]
Z-15-aMino-4,7,10,13-tetraoxapentadecacanoic acid | [CAS]
756526-00-8 | [Synonyms]
CBZ-NH-PEG4-COOH
CBZ-NH-PEG4-acid
CBZ-AMINO-PEG4-ACID
Cbz-NH-PEG4-C2-acid
Z-NH-PEG4-CH2CH2COOH
Cbz-N-amido-PEG4-acid
CBZ-N-AMIDO-PEG4-COOH
CBZ-NH-PEG4-CH2CH2COOH
CBZ-NH-PEG?-CH?CH?COOH
CBZ-N-amido-dPEG??-acid
CBZ-NH-PEG4-propionic acid
Z-15-aMino-4,7,10,13-tetraoxapentadecacanoic acid
CBZ-15-aMino-4,7,10,13-tetraoxapentadecacanoic acid
CBZ-NH-PEG4-CH2CH2COOH
3-Oxo-1-phenyl-2,7,10,13,16-pentaoxa-4-azanonadecan-19-oic acid
5,8,11,14-Tetraoxa-2-azaheptadecanedioic acid 1-(phenylmethyl) ester | [Molecular Formula]
C19H29NO8 | [MDL Number]
MFCD11041139 | [MOL File]
756526-00-8.mol | [Molecular Weight]
399.44 |
| Chemical Properties | Back Directory | [Boiling point ]
571.2±50.0 °C(Predicted) | [density ]
1.188±0.06 g/cm3(Predicted) | [storage temp. ]
2-8°C | [form ]
Liquid | [pka]
4.28±0.10(Predicted) | [color ]
Colorless to light yellow |
| Hazard Information | Back Directory | [Description]
Cbz-N-amido-PEG4-acid is a PEG linker containing a CBZ-protected amino group and a terminal carboxylic acid. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond. The hydrophilic PEG spacer increases solubility in aqueous media. The protected amine can be deprotected by acidic conditions. | [Uses]
Cbz-NH-PEG4-C2-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. | [IC 50]
PEGs; Alkyl/ether | [References]
[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005 |
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