| Identification | Back Directory | [Name]
1-(4-CHLORO-BENZYL)-1 H-INDOLE-3-CARBALDEHYDE | [CAS]
75629-57-1 | [Synonyms]
CS-1229
Oncrasin 1
ZERO/008607
ZINC00439476
AKOS B014321
Oncrasin 1 >
ASISCHEM N15726
CHEMBRDG-BB 5601604
ART-CHEM-BB B014321
1-(4-chlorobenzyl)indole-3-carbaldehyde
Oncrasin-1 - CAS 75629-57-1 - Calbiochem
1-(4-CHLORO-BENZYL)-1 H-INDOLE-3-CARBALDEHYDE
1-(4-Chlorobenzyl)-1H-indole-3-carboxaldehyde
1-[(4-chlorophenyl)methyl]indole-3-carbaldehyde
1-[(4-chlorophenyl)methyl]-3-indolecarboxaldehyde
1-[(4-chlorophenyl)methyl]-1H-indole-3-carbaldehyde
1-[(4-Chlorophenyl)methyl]-1H-indole-3-carboxaldehyde
1H-Indole-3-carboxaldehyde, 1-[(4-chlorophenyl)methyl]-
1-(4-chlorobenzyl)-1H-indole-3-carbaldehyde(SALTDATA: FREE) | [Molecular Formula]
C16H12ClNO | [MDL Number]
MFCD01051808 | [MOL File]
75629-57-1.mol | [Molecular Weight]
269.73 |
| Chemical Properties | Back Directory | [Melting point ]
115.0 to 119.0 °C | [Boiling point ]
465.5±30.0 °C(Predicted) | [density ]
1.21±0.1 g/cm3(Predicted) | [storage temp. ]
Store at +4°C | [solubility ]
DMSO: ≥20mg/mL | [form ]
powder | [color ]
off-white to light tan | [Sensitive ]
Light Sensitive |
| Hazard Information | Back Directory | [Uses]
Oncrasin 1 is a proapoptotic compound. | [Definition]
ChEBI: Oncrasin-1 is a member of the class of indoles that is 1H-indole substituted by 4-chlorobenzyl and formyl groups at positions 1 and 3, respectively. It is an anti-cancer agent that is active against lung cancer cells with K-Ras mutations. It has a role as an apoptosis inducer and an antineoplastic agent. It is a member of indoles, a member of monochlorobenzenes and an arenecarbaldehyde. | [Biological Activity]
Proapoptotic agent that induces abnormal nuclear aggregation of PKC ι and suppresses RNA transcription. Exhibits antiproliferative effects against various human tumor cell lines with K-Ras mutations (IC 50 ≤ 3 μ M) with minimal effects on normal epithelial cells and inhibits human xenograft growth by 75% in vivo . | [storage]
+4°C |
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