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ChemicalBook--->CAS DataBase List--->74578-01-1

74578-01-1

74578-01-1 Structure

74578-01-1 Structure
IdentificationBack Directory
[Name]

NSC135784
[CAS]

74578-01-1
[Synonyms]

Thaspine HCl
Thaspine HCl, NSC 135784
[Molecular Formula]

C22H23NO8
[MOL File]

74578-01-1.mol
[Molecular Weight]

429.43
Hazard InformationBack Directory
[Description]

Thaspine, also known as NSC 135784, is a natural compound and a potent topoisomerase IB inhibitor. Taspine downregulates VEGF expression and inhibits proliferation of vascular endothelial cells through PI3 kinase and MAP kinase signaling pathways. Taspine isolated from Radix et Rhizoma Leonticis inhibits proliferation and migration of endothelial cells as well as chicken chorioallantoic membrane neovascularisation. Croton lechleri sap and isolated alkaloid taspine exhibit inhibition against human melanoma SK23 and colon cancer HT29 cell lines.
[Uses]

Thaspine acetate, an alkaloid, is a topoisomerase I and II inhibitor. Thaspine acetate induces cancer cell apoptosis. Thaspine acetate induces Bak and Bax activation, mitochondrial cytochrome c release and mitochondrial membrane permeabilization. Thaspine acetate can be isoalted from the cortex of the South American tree Croton lechleri[1].
[IC 50]

Topoisomerase I; Topoisomerase II; Bax; Bak
[References]

[1] Fayad W, et al. Identification of a novel topoisomerase inhibitor effective in cells overexpressing drug efflux transporters. PLoS One. 2009 Oct 2;4(10):e7238. DOI:10.1371/journal.pone.0007238
74578-01-1 suppliers list
Company Name: TargetMol Chemicals Inc.
Tel:
Website: www.targetmol.com/
Company Name: TargetMol Chemicals Inc.
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Website:
Company Name: TargetMol Chemicals Inc.  
Tel: 15002134094
Website: https://www.targetmol.cn/
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