| Identification | Back Directory | [Name]
(+/-)-chloro-APB | [CAS]
74115-01-8 | [Synonyms]
(+/-)-chloro-APB
SKF 82958 hydrobromide,SKF82958 hydrobromide
(±)-SKF 82958 HYDROBROMIDE;CHLORO-APB HYDROBROMIDE
6-Chloro-2,3,4,5-tetrahydro-1-phenyl-3-(2-propen-1-yl)-1H-3-benzazepine-7,8-diol hydrobromide
1H-3-Benzazepine-7,8-diol,6-chloro-2,3,4,5-tetrahydro-1-phenyl-3-(2-propen-1-yl)-, hydrobromide (1:1) | [Molecular Formula]
C19H21BrClNO2 | [MOL File]
74115-01-8.mol | [Molecular Weight]
410.74 |
| Chemical Properties | Back Directory | [Melting point ]
203-204 °C(Solv: isopropanol (67-63-0); ethyl ether (60-29-7)) | [storage temp. ]
Store at -20°C | [solubility ]
DMSO: 100 mM; Water: 5 mM, with warming | [form ]
A solid | [color ]
White to off-white |
| Hazard Information | Back Directory | [Hazard]
A poison. | [Uses]
SKF 82958 Hydrobromide is a dopamine (D1) agonist. Also, it augments GABAB inhibitory post-synaptic potentials (ipsp) in ventral tegmental area in brain slices. | [in vivo]
SKF-82958 ((±)-SKF 82958) hydrobromide (0.003-0.1 mg/kg; i.p.) results in dose-dependent increases in responding on the SKF-82958 appropriate lever, with full substitution following administration of the SKF-82958 hydrobromide training dose 0.03 mg/kg. Increasing the dose of SKF-82958 hydrobromide also results in a significant reduction in response rate[2].
?
SKF-82958 hydrobromide (0.5-2.0 mg/kg; i.p) significantly suppresses pilocarpine-induced jaw movements[3].
| Animal Model: | Male Sprague-Dawley rats[3] | | Dosage: | 0.5-2.0 mg/kg | | Administration: | I.p | | Result: | Significantly reduced the number of tremulous jaw movements induced by 4.0 mg/kg pilocarpine.
|
| [IC 50]
D1 Receptor | [storage]
Store at -20°C |
|
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