| Identification | Back Directory | [Name]
2'-HYDROXY-2,4,4',5,6'-PENTAMETHOXYCHALCONE | [CAS]
73694-15-2 | [Synonyms]
RUBONE
Rubone >=98% (HPLC)
2'-HYDROXY-2,4,4',5,6'-PENTAMETHOXYCHALCONE
2'-HYDROXY-2,4,5,4',6'-PENTAMETHOXYCHALCONE
2,4,5-Trimethoxybenzylidene(2-hydroxy-4,6-dimethoxyacetophenone)
Rubone~2,4,5-Trimethoxybenzylidene(2-hydroxy-4,6-dimethoxyacetophenone)
2-Propen-1-one, 1-(2-hydroxy-4,6-dimethoxyphenyl)-3-(2,4,5-trimethoxyphenyl)-, (2E)- | [Molecular Formula]
C20H22O7 | [MDL Number]
MFCD00274772 | [MOL File]
73694-15-2.mol | [Molecular Weight]
374.38 |
| Chemical Properties | Back Directory | [Boiling point ]
586.1±50.0 °C(Predicted) | [density ]
1.214±0.06 g/cm3(Predicted) | [storage temp. ]
2-8°C | [solubility ]
DMSO: 2mg/mL, clear (warmed) | [form ]
powder | [pka]
6.79±0.40(Predicted) | [color ]
yellow to orange |
| Hazard Information | Back Directory | [Definition]
ChEBI:Rubone is a member of chalcones. | [Biological Activity]
Rubone has strong anticancer activity. Rubone and paclitaxel (PTX) combination therapy retarded cancer cell growthmigration and cancer stem-like cells (CSC) population growth.''Rubone is a miR34a modulator th at specifically restores miR34a in hepatocellular carcinoma cells with wild-type or mutated p53. Rubone potently inhibits growth of hepatocellular carcinoma in a mouse xenograft model. Rubone does not effect the growth of nontumorigenic human hepatocytes.''Rubone is a miR34a modulator th at specifically restores miR34a in hepatocellular carcinoma cells. |
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