| Identification | Back Directory | [Name]
macbecin I | [CAS]
73341-72-7 | [Synonyms]
macbecin I
(15R)-6,17-Didemethoxy-15-methoxy-6-methyl-11-O-methyl-geldanamycin
(6S,15R)-6,17-Didemethoxy-15-methoxy-6-methyl-11-O-methylgeldanamycin
Geldanamycin, 6,17-didemethoxy-15-methoxy-6-methyl-11-O-methyl-, (15R)- | [Molecular Formula]
C30H42N2O8 | [MOL File]
73341-72-7.mol | [Molecular Weight]
558.67 |
| Chemical Properties | Back Directory | [Melting point ]
205-206 °C(Solv: ethanol (64-17-5); water (7732-18-5)) | [Boiling point ]
736.2±60.0 °C(Predicted) | [density ]
1.17±0.1 g/cm3(Predicted) | [storage temp. ]
Desiccate at -20°C | [solubility ]
Soluble in DMSO > 10 mM | [form ]
Powder | [pka]
8.62±0.70(Predicted) |
| Hazard Information | Back Directory | [Uses]
Macbecin I is an ansamycin antibiotic inhibitor of Hsp90 activity. | [Biological Activity]
Ansamycin antibiotic compound that inhibits Hsp90 activity (IC 50 = 2 μ M) by binding to the ATP-binding site. Exhibits antitumor and cytocidal activities (IC 50 ~ 0.4 μ M) by causing degradation of key oncogenic client proteins such as ErbB2 and cRaf1. Displays higher affinity and potency than geldanamycin (9,13-Dihydroxy-8,14,19-trimethoxy-4,10,12,16-tetramethyl-2-azabicyclo[16.3.1]docosa-4,6,10,18,21-pentaene-3,20,22-trione, 9-carbamate ). | [IC 50]
HSP90: 2 μM (IC50); HSP90: 0.24 μM (Kd) | [storage]
Desiccate at -20°C |
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