| Identification | Back Directory | [Name]
Methylnissolin | [CAS]
73340-41-7 | [Synonyms]
Medicarpi
3-Hydroxy-9
Methylnissolin
Astrapterocarpan
METHYLNISSOLIN (ASTRAPTEROCARPAN)
3-Hydroxy-9,10-dimethoxyptercarpan
L-3-Hydroxy-9,10-dimethoxylpterocarpan
3-Hydroxy-9,10-dimethoxyptercarpanMedicarpin
3-Hydroxy-9,10-dimethoxyptercarpan,Methylnissolin
3-Hydroxy-9,10-dimethoxyptercarpan,Medicarpin,Methylnissolin
(-)-6aR,11aR-dihydro-3-hydroxy-9,10-dimethoxy-6H-benzofuro[3,2-c][1]-benzopyran
6H-Benzofuro[3,2-c][1]benzopyran-3-ol, 6a,11a-dihydro-9,10-dimethoxy-, (6aR,11aR)- | [Molecular Formula]
C17H16O5 | [MDL Number]
MFCD08061495 | [MOL File]
73340-41-7.mol | [Molecular Weight]
300.31 |
| Chemical Properties | Back Directory | [Boiling point ]
428.9±45.0 °C(Predicted) | [density ]
1.312 | [storage temp. ]
4°C, protect from light | [solubility ]
Acetone: soluble; Chloroform: soluble; Dichloromethane: soluble; DMSO: soluble; Ethyl Acetate: soluble | [form ]
A solid | [pka]
9.44±0.20(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
Methylnissolin (Astrapterocarpan), isolated from Astragalus membranaceus, inhibits platelet-derived growth factor (PDGF)-BB-induced cell proliferation with an IC50 of 10 μM. Methylnissolin inhibits PDGF-BB-induced phosphorylation of extracellular signal-regulated kinase 1/2 (ERIC1/2) mitogen-activated protein (MAP) kinase. Methylnissolin inhibits PDGF-BB-induced vascular smooth muscle cell proliferation by inhibition of the ERK1/2 MAP kinase cascade[1]. | [Definition]
ChEBI: Astrapterocarpan is a member of pterocarpans. | [IC 50]
PDGFR: 10 μM (IC50); ERK1; ERK2 | [References]
[1] Ohkawara S, et al. Astrapterocarpan isolated from Astragalus membranaceus inhibits proliferation of vascular smooth muscle cells. Eur J Pharmacol. 2005 Nov 21;525(1-3):41-7. DOI:10.1016/j.ejphar.2005.08.063 |
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