| Identification | Back Directory | [Name]
Cyclohexyl-[2-(3,5-dimethyl-pyrazol-1-yl)-6-methyl-pyrimidin-4-yl]-amine | [CAS]
73029-73-9 | [Synonyms]
CyPPA
N-Cyclohexyl-2-(3,5-dimethyl-1H-pyrazol-1-yl)
N-Cyclohexyl-N-[2-(3,5-diMethyl-pyrazol-1-yl)-6-Methyl-4-pyriMid
N-Cyclohexyl-N-[2-(3,5-dimethyl-pyrazol-1-yl)-6-methyl-4-pyrimidinamine
N-Cyclohexyl-2-(3,5-dimethyl-1H-pyrazol-1-yl)-6-methylpyrimidin-4-amine
Cyclohexyl-[2-(3,5-dimethyl-pyrazol-1-yl)-6-methyl-pyrimidin-4-yl]-amine
4-PyriMidinaMine, N-cyclohexyl-2-(3,5-diMethyl-1H-pyrazol-1-yl)-6-Methyl-
N-Cyclohexyl-N-[2-(3,5-dimethylpyrazol-1-yl)-6-methylpyrimidin-4-yl]amine | [Molecular Formula]
C16H23N5 | [MDL Number]
MFCD01550586 | [MOL File]
73029-73-9.mol | [Molecular Weight]
285.39 |
| Chemical Properties | Back Directory | [Boiling point ]
512.2±42.0 °C(Predicted) | [density ]
1.23 | [storage temp. ]
2-8°C | [solubility ]
DMSO: >10mg/mL | [form ]
solid | [pka]
4.19±0.10(Predicted) | [color ]
white |
| Hazard Information | Back Directory | [Uses]
CyPPA has been used:
- to test its inhibitory functionality on melanogenesis
- as an activator of small conductance potassium channel-3 (SK3) in mesenteric artery segments
- in the activation of calcium-activated potassium (SK) channels in murine hippocampal neurons HT-22 cells
| [Uses]
CyPPA is a positive SK3/SK2 modulator that reduces the activity of dopaminergic neurons, inhibits dopamine release, and counteracts hyperdopaminergic behaviors induced by methyl phenidate. | [Biological Activity]
Activator of small conductance Ca 2+ -activated K + channels that displays selectivity for SK2 and SK3 channels (EC 50 values are 5.6 and 14 μ M for SK3 and SK2 respectively). Displays no activity at SK1 and IK channels. | [Biochem/physiol Actions]
CyPPA is a positive modulator of small conductance Ca2+-activated K+ channels; selective for SK3 and SK2. CyPPA is a first subtype selective SK channel positive modulator with an EC50 of 5.6 μM and 14 μM, efficacy 90% and 71% for hSK3 and hSK2, respectively. CyPPA is a tool for distinguishing SK2 and SK3 from SK1 and IK; no other agents distinguish these channels. | [storage]
Store at -20°C |
|
| Company Name: |
Sigma-Aldrich
|
| Tel: |
021-61415566 800-8193336 |
| Website: |
https://www.sigmaaldrich.cn |
|