| Identification | Back Directory | [Name]
STATIL | [CAS]
72702-95-5 | [Synonyms]
STATIL
MK-538
ICI-plc
ICI-128436
Ponalrestat
Ponalrestat (MK-538
[3-(4-BROMO-2-FLUOROBENZYL)-4-OXO-3H-PHTHALAZIN-1-YL]ACETIC ACID
Ponalrestat Statil
3-(4-BROMO-2-FLUOROBENZYL)-4-OXO-3H-PHTHALAZIN-1-YL]ACETIC ACID (STATIL)
2-(3-(4-broMo-2-fluorobenzyl)-4-oxo-3,4-dihydrophthalazin-1-yl)acetic acid
3-[(4-Bromo-2-fluorophenyl)methyl]-3,4-dihydro-4-oxo-1-phthalazineacetic acid | [Molecular Formula]
C17H12BrFN2O3 | [MDL Number]
MFCD00204117 | [MOL File]
72702-95-5.mol | [Molecular Weight]
391.19 |
| Chemical Properties | Back Directory | [Melting point ]
184-186℃ (DEC.) | [density ]
1.60 | [storage temp. ]
Store at RT | [solubility ]
DMF: 2 mg/mL; DMSO: 2 mg/mL; Ethanol: 2 mg/mL; PBS (pH 7.2): 0.2 mg/mL | [form ]
A crystalline solid | [color ]
White to off-white |
| Hazard Information | Back Directory | [Description]
Statil is an aldose reductase inhibitor that blocks the conversion of glucose to sorbitol. It demonstrates selectivity for aldose reductase 2 over aldose reductase 1 with Ki values of 7.7 nM and 60 μM, respectively. Statil has been shown to prevent diabetes-induced alterations of the cardiovascular system in 14-day streptozotocin-diabetic rats. Aldose reductase inhibition by statil has also been used to impair the synthesis of prostaglandin F2α by human cultured preadipocytes. | [Uses]
Inhibitor (aldose reductase). | [Definition]
ChEBI: 2-[3-[(4-bromo-2-fluorophenyl)methyl]-4-oxo-1-phthalazinyl]acetic acid is a member of phthalazines. | [Biological Activity]
Potent aldose reductase inhibitor. |
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China Langchem Inc.
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D&C Chemicals
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