| Identification | Back Directory | [Name]
2-[2-(3-quinolyl)-4-pyridyl]-1,5,6,7-tetrahydropyrrolo[3,2-c]pyridin-4-one | [CAS]
724711-21-1 | [Synonyms]
MK2-IN-3
MK2 Inhibitor III (MK2-IN-3)
2-[2-(3-quinolyl)-4-pyridyl]-1,5,6,7-tetrahydropyrrolo[3,2-c]pyridin-4-one
2-(2-(Quinolin-3-yl)pyridin-4-yl)-6,7-dihydro-1H-pyrrolo[3,2-c]pyridin-4(5H)-one
MAPK activated protein kinase 2,Mitogen-activated protein kinase activated protein kinase 2,inhibit,MK-2,Inhibitor,MAPKAPK2 (MK2),MK-5,MAPKAP kinase 2,ERK2,MAP kinase activated protein kinase 2,MK2IN3,MK-3,TNFα,MNK1,MK2 IN 3,MK-2-IN-3,MAPKAP-K2 | [Molecular Formula]
C21H16N4O | [MOL File]
724711-21-1.mol | [Molecular Weight]
340.38 |
| Chemical Properties | Back Directory | [Boiling point ]
721.1±60.0 °C(Predicted) | [density ]
1.318±0.06 g/cm3(Predicted) | [storage temp. ]
4°C, protect from light | [solubility ]
DMSO : 62.5 mg/mL (183.62 mM) | [form ]
Solid | [pka]
13.80±0.20(Predicted) | [color ]
Off-White to Pale Yellow |
| Hazard Information | Back Directory | [Uses]
MK2 Inhibitor III is a potent, cell-permeable inhibitor of mitogen-activated protein kinase-activated protein kinase 2 (MAPKAP-K2 or MK-2) and can be used for the treatment of rheumatoid arthritis. | [in vivo]
MK2-IN-3 (compound 16) (20 mg/kg; a single p.o. before LPS challenge) inhibits 20% TNFα production in rat LPS (rLPS) model[1]. | [storage]
4°C, protect from light |
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DC Chemicals
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