| Identification | Back Directory | [Name]
benzyldimethyl(2-phenoxyethyl)ammonium | [CAS]
7181-73-9 | [Synonyms]
benzyldimethyl(2-phenoxyethyl)ammonium
N,N-Dimethyl-N-(2-phenoxyethyl)benzenemethanaminium | [EINECS(EC#)]
230-546-7 | [Molecular Formula]
C17H22NO+ | [MOL File]
7181-73-9.mol | [Molecular Weight]
256.363 |
| Hazard Information | Back Directory | [Originator]
Alcopar,Wellcome,UK,1960 | [Definition]
ChEBI: Bephenium is an aromatic amine. | [Manufacturing Process]
First, dimethylamino-2-phenoxyethanewas made by reacting chloro-2-
phenoxyethane with dimethylamine. Benzyl chloride (10 grams) was then
added to a solution of 1-dimethylamino-2-phenoxyethane (12.3 grams) in
acetone (35 ml). The mixture warmed spontaneously and N-benzyl-N,Ndimethyl-N-2-phenoxyethylammonium chloride slowly crystallized. After 24
hours, this solid was filtered off, washed with fresh acetone and dried
immediately in vacuo, MP 135°-136°C.
2-Hydroxy-3-naphthoic acid (1.88 grams) was dissolved in hot aqueous
sodium hydroxide (0.5N; 20 ml) and the resulting solution was slowly added
to a solution of N-benzyl-N,N-dimethyl-N-2-phenoxyethylammonium chloride
(2.9 grams) in water (5 ml). A gum separated at first but it solidified on
scratching. After the addition was complete, the mixture was allowed to stand
at room temperature for 2 hours and then filtered. The residue was washed
with water and dried in vacuo to give N-benzyl-N,N-dimethyl-N-2-
phenoxyethylammonium 2-hydroxy-3-naphthoate, MP 170°-171°C. | [Therapeutic Function]
Anthelmintic | [storage]
Store at -20°C |
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