| Identification | Back Directory | [Name]
N-(2,3-DIPHENYL-1,2,4-THIADIAZOL-5(2H)-YLIDENE)METHANAMINE HYDROBROMIDE | [CAS]
70375-43-8 | [Synonyms]
SCH-202676
SCH202676 HBr
SCH-202676 HBr
SCH 202676 HBr
AURORA KA-7903
SCH 202676 HYDROBROMIDE
Methanamine, N-(2,3-diphenyl-1,2,4-thiadiazol-5(2H)-ylidene)-
N-(2,3-DIPHENYL-1,2,4-THIADIAZOL-5-(2H)-YLIDENE)METHANAMINE, HBR
N-(2,3-DIPHENYL-1,2,4-THIADIAZOL-5(2H)-YLIDENE)METHANAMINE HYDROBROMIDE | [Molecular Formula]
C15H13N3S | [MDL Number]
MFCD06671539 | [MOL File]
70375-43-8.mol | [Molecular Weight]
267.35 |
| Chemical Properties | Back Directory | [Melting point ]
240.0-240.8 °C(lit.) | [storage temp. ]
Desiccate at +4°C | [solubility ]
DMSO: 40 mg/mL | [form ]
Yellow solid. | [color ]
Beige | [Stability:]
Stable for 1 year from date of purchase as supplied. Protect from exposure to moisture. Solutions in DMSO may be stored at -20°C for up to 3 months. |
| Hazard Information | Back Directory | [Description]
SCH-202676 (70375-43-8) is a reversible inhibitor of both agonist and antagonist binding to G protein-coupled receptors (GPCRs).1 IC50‘s = 0.1-1.7 μM for nine GPCRs.1 Modification of GPCRs is accomplished via sulfhydryl modification.2,3 | [Uses]
SCH-202676 hydrobromide is a modulator that inhibits binding to G protein-coupled receptors. | [Biological Activity]
Sulphydryl-reactive compound that inhibits agonist and antagonist binding to G-protein-coupled receptors. Inhibits a variety of GPCRs including adenosine, opioid, muscarinic, adrenergic and dopaminergic receptors (IC 50 values are 0.1-1.8 μ M). | [storage]
Store at -20°C | [References]
1) Fawzi et al. (2001), SCH-202676: an allosteric modulator of both agonist and antagonist binding to G protein-coupled receptors; Mol.Pharmacol. 59 30
2) Lewandowicz et al. (2006), The allosteric modulator SCH-202676 disrupts G protein-coupled receptor function via sulphydryl-sensitive mechanisms; Br. J. Pharmacol. 147 422
3) Goblyos et al. (2005), Synthesis and biological evaluation of a new series of 2,3,5-substituted[1,2,4]-thiadiazoles as modulators of adenosine A1 receptors and their molecular mechanism of action; J. Med. Chem., 48 1145 |
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