| Identification | Back Directory | [Name]
Gly-Arg-AMC (hydrochloride) | [CAS]
70274-78-1 | [Synonyms]
Gly-Arg-AMC (hydrochloride)
(S)-2-(2-aminoacetamido)-5-((diaminomethylene)amino)-N-(4-methyl-2-oxo-2H-chromen-7-yl)pentanamide | [Molecular Formula]
C18H25ClN6O4 | [MOL File]
70274-78-1.mol | [Molecular Weight]
424.89 |
| Chemical Properties | Back Directory | [storage temp. ]
Store at -20°C | [solubility ]
DMF: 30 mg/ml; DMSO: 30 mg/ml; DMSO:PBS (pH 7.2) (1:1): 0.5 mg/ml; Ethanol: 20 mg/ml | [form ]
A solid |
| Hazard Information | Back Directory | [Description]
Gly-Arg-AMC is a fluorogenic substrate for cathepsin C.1 Upon enzymatic cleavage by cathepsin C, 7-amino-4-methylcoumarin (AMC) is released and its fluorescence can be used to quantify cathepsin C activity. AMC displays excitation/emission maxima of 340-360/440-460 nm, respectively. | [References]
1. Rubach, J.K., Cui, G., Schneck, J.L., et al. The amino-acid substituents of dipeptide substrates of cathepsin C can determine the rate-limiting steps of catalysis Biochemistry 51(38),7551-7568(2012). |
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