| Identification | Back Directory | [Name]
Avermectin A1a, 5-O-demethyl-25-de(1-methylpropyl)-22,23-dihydro-25-(1-methylethyl)- | [CAS]
70209-81-3 | [Synonyms]
Component B1b
Ivermectin B1b
IvermectinH2B1b
avermectin H2B1b
Dihydroavermectin B1b
22,23-Dihydroavermectin B1b
22,23- dihydroavermectin B1b (Ivermectin B1b)
22,23-Dihydro-34-nor-5-O-demethylavermectin A1a
DihydroaverMectin B1b, 22,23-DihydroaverMectin B1b
22,23-Dihydro-5-O-demethyl-25-de(1-methylpropyl)-25-isopropylavermectin A1a
5-O-Demethyl-25-de(1-methylpropyl)-22,23-dihydro-25-(1-methylethyl)avermectin A1a
Avermectin A1a, 5-O-demethyl-25-de(1-methylpropyl)-22,23-dihydro-25-(1-methylethyl)- | [EINECS(EC#)]
274-384-5 | [Molecular Formula]
C47H72O14 | [MDL Number]
MFCD00866559 | [MOL File]
70209-81-3.mol | [Molecular Weight]
861.07 |
| Chemical Properties | Back Directory | [Boiling point ]
934.1±65.0 °C(Predicted) | [density ]
1.24±0.1 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
DMF: Soluble; DMSO: Soluble; Ethanol: Soluble; Methanol: Soluble | [form ]
A solid | [pka]
12.42±0.70(Predicted) | [Stability:]
Temperature sensitive |
| Hazard Information | Back Directory | [Uses]
Ivermectin B1b (dihydroavermectin B1b) is the minor component (<20%) of the commercial anthelmintic, ivermectin. Members of the avermectin/milbemycin anthelmintic class exert their anthelmintic effects by binding to glutamate-gated chloride channels expressed on nematode neurones and pharyngeal muscle cells. The avermectin/milbemycins are also potent insecticides. In vitro, the B1b (25-iso-propyl) analogue is slightly more potent than the 25-sec-butyl (B1a) analogue as an inhibitor of nematode larval development and paralysis, and also a more sensitive probe for ivermectin resistance. | [Definition]
ChEBI: A macrocyclic lactone that is avermectin B1b in which the double bond present in the spirocyclic ring system has been reduced to a single bond. It is the minor component of ivermectin. | [Brand name]
Stromectol (Merck). | [storage]
Store at -20°C |
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